Alpha tryptase allele of Tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines

Human Immunology
Clara Vasquez VelasquezKenji Hirayama

Abstract

We previously reported, significantly higher levels of Chymase and Tryptase in early stage plasma of DSS patients prior to the occurrence of shock suggesting a possible role of mast cells in dengue pathogenesis. To further investigate, we analyzed CMA1 promoter SNP (rs1800875) and TPSAB1 gene alleles, which encode the Human Chymase and α- and β- tryptase 1 enzymes respectively, for susceptibility to Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in patients from hospitals in Vietnam (Ho Chi Minh City and Vinh Long) and the Philippines. While the CMA1 promoter SNP (rs1800875) was not associated with DHF/DSS, the homozygous form of α-tryptase allele was associated with DSS patients in Vinh Long and the Philippines (OR=3.52, p<0.0001; OR=3.37, p<0.0001, respectively) and with DHF in Ho Chi Minh City (OR=2.54, p=0.0084). Also, a statistically significant association was observed when DHF and DSS were combined in Vinh Long (OR=1.5, p=0.034) and the Philippines (OR=2.36, p=0.0004); in Ho Chi Minh City when DHF and DSS were combine an association was observed, but it was not statistically significant (OR=1.5, p=0.0505). Therefore, the α-tryptase might have a possible effect on the susceptibility to severe form of Dengu...Continue Reading

References

Jan 28, 1999·The Journal of Biological Chemistry·M PallaoroG H Caughey
May 21, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K TanakaJ Furuyama
Nov 7, 1999·The Journal of Allergy and Clinical Immunology·S ForrestR Williamson
Jul 9, 2004·The Journal of Allergy and Clinical Immunology·Hae-Ki MinLawrence B Schwartz
Jul 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T IwanagaJ W Holloway
Jan 22, 2005·Nature Immunology·Stephen J GalliMindy Tsai
Apr 28, 2006·The FEBS Journal·Jenny Hallgren, Gunnar Pejler
Apr 24, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Cem AkinDean D Metcalfe
May 15, 2007·Immunological Reviews·George H Caughey
Sep 15, 2009·The Journal of Allergy and Clinical Immunology·Neil N TrivediGeorge H Caughey
Oct 14, 2009·Clinical Microbiology Reviews·Byron E E MartinaAlbert D M E Osterhaus
May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ashley L St JohnSoman N Abraham
Mar 1, 2012·PLoS Neglected Tropical Diseases·Takahisa FurutaNaohiro Watanabe
Apr 6, 2013·Nature Reviews. Immunology·David Voehringer
May 3, 2013·ELife·Panisadee Avirutnan, Ponpan Matangkasombut
Jan 1, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M AbdelmotelbJ W Holloway

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Citations

May 10, 2017·DNA and Cell Biology·Berlin Londono-RenteriaTonya M Colpitts
Apr 26, 2019·PLoS Neglected Tropical Diseases·Kristal An AgrupisJacqueline Deen
Jul 25, 2019·The Journal of Experimental Medicine·Quang T LeLawrence B Schwartz
Jan 20, 2018·Transactions of the Royal Society of Tropical Medicine and Hygiene·Dorothy NgSuranjith L Seneviratne
Sep 1, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Caroline ManetXavier Montagutelli
Feb 15, 2019·Viruses·Harshada KetkarPenghua Wang
Feb 6, 2021·PloS One·Tehani SilvaGathsaurie Neelika Malavige
May 2, 2021·Current Opinion in Immunology·Jonathan J Lyons, Tangsheng Yi
Jan 9, 2018·ACS Applied Materials & Interfaces·Lei LuLarry D Unsworth

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