PMID: 15218045Jun 26, 2004Paper

Alpha v beta 3 integrin expression in human odontoblasts and co-localization with osteoadherin

Journal of Dental Research
M LucchiniJ-C Farges

Abstract

Integrins are heterodimeric transmembrane receptors which promote cell adhesion, thus contributing to the maintenance of tissue organization in both normal and pathological conditions. To characterize the way odontoblasts may interact with other cells and the extracellular matrix in human teeth, we studied expression of alpha v beta 3 integrin, a putative receptor for osteoadherin. We showed that alpha v beta 3 integrin expression was restricted to odontoblasts, blood vessels, and small rounded cells in sound and carious pulp. Odontoblast staining intensity increased from the apical to the cusp region. Osteoadherin staining was strong in the whole odontoblast layer (with a slight decrease in the cusp region) and in predentin. Odontoblasts differentiating in vitro were stained with the anti-alpha v beta 3 integrin antibody, first at the level of intercellular contacts, then throughout the cell membrane. These results suggest that the alpha v beta 3 integrin could play a role in interodontoblast adhesion and odontoblast binding to the surrounding predentin/dentin/pulp matrix, possibly through osteoadherin.

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Citations

Dec 13, 2005·Cell and Tissue Research·M-J StaquetJ-C Farges
Aug 24, 2007·Biochemical and Biophysical Research Communications·Ken NinomiyaToshio Suda
Oct 12, 2010·Journal of Dental Research·J K KimE E Hill
Sep 20, 2017·PloS One·K R Torres-da-SilvaC A Casatti
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Mar 3, 2007·Archives of Oral Biology·Stéphanie H DurandJean-Christophe Farges

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