PMID: 7538977May 16, 1995Paper

Alpha v-integrins in human melanoma: gain of alpha v beta 3 and loss of alpha v beta 5 are related to tumor progression in situ but not to metastatic capacity of cell lines in nude mice

International Journal of Cancer. Journal International Du Cancer
E H DanenG N van Muijen

Abstract

We investigated the expression of alpha v-integrins in different stages of human cutaneous melanocytic tumor progression. We observed that alpha v beta 5 was the alpha v-integrin expressed in all common nevocellular nevi, in 78% of dysplastic nevi, in 63% of early primary melanomas, in 43% of advanced primary melanomas, and in 33% of melanoma metastases. Hence, loss of alpha v beta 5 expression was related to melanocytic tumor progression. In line with earlier reports, alpha v beta 3 was exclusively detected in advanced primary melanomas and metastases (24% and 50% respectively). Staining with anti-alpha v monoclonal antibodies (MAbs) in lesions where both alpha v beta 3 and alpha v beta 5 were absent showed that alternative alpha v-integrins were expressed in advanced primary melanomas and metastases. By FACS analysis, we determined expression of alpha v beta 5 and alpha v beta 3 in 4 human melanoma cell lines with different metastatic capacities after s.c. inoculation into nude mice. One of the non-metastatic and both highly metastatic cell lines expressed alpha v beta 5 at their surface. Surprisingly, alpha v beta 3 was detected exclusively in the non-metastatic cell lines. Absence of alpha v beta 3 in the highly metastatic ...Continue Reading

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Citations

Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·B KüstersR M de Waal
May 1, 1996·The British Journal of Surgery·M D Menger, B Vollmar
May 8, 2001·International Journal of Cancer. Journal International Du Cancer·G J ThomasP M Speight
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Feb 7, 2001·International Journal of Cancer. Journal International Du Cancer·T KageshitaS Ferrone
Jun 30, 2005·Cancer Metastasis Reviews·Silke KuphalAnja-Katrin Bosserhoff
Mar 21, 2020·Frontiers in Cell and Developmental Biology·Mladen ParadžikAndreja Ambriović-Ristov
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May 1, 2021·Cancers·Melina de Moraes Santos OliveiraMaria Cristina Cintra Gomes-Marcondes
Oct 1, 1996·Current Opinion in Cell Biology·J A Varner, D A Cheresh
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Aug 21, 2003·Biochemical and Biophysical Research Communications·Yongjian YangDaniel M Ramos
Sep 1, 2004·Biochemical and Biophysical Research Communications·Yongjian YangDaniel M Ramos

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