{alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium.

Circulation. Heart Failure
Brian C JensenPaul C Simpson

Abstract

alpha1-adrenergic receptors (alpha1-ARs) play adaptive roles in the heart and protect against the development of heart failure. The 3 alpha1-AR subtypes, alpha1A, alpha1B, and alpha1D, have distinct physiological roles in mouse heart, but very little is known about alpha1 subtypes in human heart. Here, we test the hypothesis that the alpha1A and alpha1B subtypes are present in human myocardium, similar to the mouse, and are not downregulated in heart failure. Hearts from transplant recipients and unused donors were failing (n=12; mean ejection fraction, 24%) or nonfailing (n=9; mean ejection fraction, 59%) and similar in age ( approximately 44 years) and sex ( approximately 70% male). We measured the alpha1-AR subtypes in multiple regions of both ventricles by quantitative real-time reverse-transcription polymerase chain reaction and radioligand binding. All 3 alpha1-AR subtype mRNAs were present, and alpha1A mRNA was most abundant ( approximately 65% of total alpha1-AR mRNA). However, only alpha1A and alpha1B binding were present, and the alpha1B was most abundant (60% of total). In failing hearts, alpha1A and alpha1B binding was not downregulated, in contrast with beta1-ARs. Our data show for the first time that the alpha1A a...Continue Reading

References

Aug 24, 1995·Biochemical and Biophysical Research Communications·C FaureD Graham
Jan 16, 1995·European Journal of Pharmacology·A S GoetzD L Saussy
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·C A MilanoR J Lefkowitz
Jun 30, 1994·Biochemical and Biophysical Research Communications·D H WeinbergM Bayne
Oct 8, 1997·The American Journal of Physiology·D Sheikh-HamadW Zhao
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·I LemireH Rindt
Mar 20, 2002·The Journal of Clinical Investigation·Akito TanoueGozoh Tsujimoto
Apr 10, 2002·Circulation·Carmine VecchioneGiuseppe Lembo
Apr 17, 2002·Circulation·Karl SwedbergUNKNOWN Moxonidine Safety and Efficacy (MOXSE) Investigators
Jul 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·D Gregg Rokosh, Paul C Simpson
Feb 22, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Lynne TurnbullAnthony J Baker
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Dan ChalothornMichael T Piascik
Nov 4, 2004·Journal of Molecular and Cellular Cardiology·Xiao-Jun DuRobert M Graham
Apr 6, 2006·The Journal of Clinical Investigation·Timothy D O'ConnellPaul C Simpson
Oct 31, 2006·American Heart Journal·Richard Shannon, Mohammad Chaudhry
Nov 8, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Brian C JensenPaul C Simpson
Sep 19, 2009·Journal of the American College of Cardiology·Brian C JensenPaul C Simpson

❮ Previous
Next ❯

Citations

Sep 22, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Brian C JensenPaul C Simpson
Jan 19, 2013·Bulletin of Experimental Biology and Medicine·N I ZiyatdinovaT L Zefirov
Feb 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Takehiro OgataTomomi Ueyama
Mar 14, 2014·Pflügers Archiv : European journal of physiology·Anthony J Baker
Mar 16, 2017·Expert Review of Cardiovascular Therapy·Chan Soon Park, Hae-Young Lee
Apr 27, 2017·The Journal of Physiology·Kristina LorenzJoachim P Schmitt
Mar 14, 2017·JACC. Basic to Translational Science·JuYoun BeakBrian C Jensen
Jan 24, 2018·Cardiovascular Research·Mélanie LambertFabrice Antigny
Dec 17, 2010·World Journal of Cardiology·Alberto J AlvesEhud Goldhammer
Jun 4, 2016·PloS One·R Croft ThomasPaul C Simpson
Feb 12, 2019·British Journal of Pharmacology·Ling Yeong ChiaMasaaki Sato
Jun 28, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Patrick M CowleyAnthony J Baker
Feb 23, 2011·Journal of Receptor and Signal Transduction Research·Dianne M Perez, Van A Doze
Sep 8, 2019·The Journal of Pharmacology and Experimental Therapeutics·Randy Torralva, Aaron Janowsky
Jun 12, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Fermí MontóPilar D'Ocon
Nov 18, 2011·Journal of Muscle Research and Cell Motility·Sonya C BardswellMetin Avkiran
Dec 5, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Jiandong ZhangBrian C Jensen
Dec 5, 2020·International Journal of Endocrinology·Abril Carbajal-GarcíaLuis M Montaño
Jul 28, 2016·JACC. Basic to Translational Science·R Croft ThomasPaul C Simpson
Jun 3, 2021·International Journal of Molecular Sciences·Dianne M Perez
Jun 12, 2021·Frontiers in Cell and Developmental Biology·Dianne M Perez
Sep 19, 2009·Journal of the American College of Cardiology·Brian C JensenPaul C Simpson
Dec 2, 2010·Journal of Molecular and Cellular Cardiology·Brian C JensenPaul C Simpson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.