Alpha1-adrenoceptor subtypes and alpha1-adrenoceptor antagonists

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
I MuramatsuS Morishima

Abstract

Alpha(1)-adrenoceptors are widely distributed in the human body and play important physiologic roles. Three alpha(1)-adrenoceptor subtypes (alpha(1A), alpha(1B) and alpha(1D)) have been cloned and show different pharmacologic profiles. In addition, a putative alpha(1)-adrenoceptor (alpha(1L) subtype) has also been proposed. Recently, three drugs (tamsulosin, naftopidil, and silodosin) have been developed in Japan for the treatment of urinary obstruction in patients with benign prostatic hyperplasia. In this review, we describe recent alpha(1)-adrenoceptor subclassifications and the pharmacologic characteristics (subtype selectivity and clinical relevance) of alpha(1)-adrenoceptor antagonists.

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Citations

Nov 29, 2007·Expert Opinion on Investigational Drugs·Masaki YoshidaKazuki Kawabe
Oct 29, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Lili Sepehr-AraMassoud Mahmoudian

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