PMID: 10764825Apr 15, 2000Paper

alpha1,2Fucosyltransferase increases resistance to apoptosis of rat colon carcinoma cells

Glycobiology
C GoupilleJacques Le Pendu

Abstract

Accumulation of histo-blood group antigens such as Lewis b, Lewis Y and H in colon cancer is indicative of poor prognosis. It is accompanied by increase in alpha1,2fucosyl-transferase activity, a key enzyme for synthesis of these antigens. Using a model of colon carcinoma, we previously showed that alpha1,2fucosylation increases tumorigenicity. We now show that tumorigenicity inversely correlates with the cells' sensitivity to apoptosis. In addition, poorly tumorigenic REG cells independently transfected with three different alpha1,2fucosyltransferase cDNAs, the human FUT1, the rat FTA and FTB were more resistant than control cells to apoptosis induced in vitro by serum deprivation. Inversely, PRO cells, spontaneously tumorigenic in immunocompetent syngeneic animals and able to synthesize alpha1,2fucosylated glycans, became more sensitive to apoptosis after transfection with a fragment of the FTA cDNA in the antisense orientation. Expression of alpha1,2fucosyl-transferase in poorly tumorigenic REG cells dramatically enhanced their tumorigenicity in syngeneic rats. However, in immunodeficient animals, both control and alpha1,2fuco-syltransferase transfected REG cells were fully tumorigenic and metastatic, indicating that the pre...Continue Reading

References

Dec 2, 1992·International Journal of Cancer. Journal International Du Cancer·R ZennadiJ Le Pendu
Aug 15, 1985·International Journal of Cancer. Journal International Du Cancer·A CaignardF Martin
Nov 15, 1983·International Journal of Cancer. Journal International Du Cancer·F MartinM Martin
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·J SunM Blaszczyk-Thurin
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·F HallouinJ Le Pendu

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Citations

Aug 3, 2005·Cancer Immunology, Immunotherapy : CII·Piotr LaidlerElzbieta Kremser
Mar 19, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Erik Dabelsteen
Aug 16, 2002·European Journal of Biochemistry·Anne Cailleau-ThomasJacques Le Pendu
Nov 15, 2001·Advances in Anatomic Pathology·J J ListinskyG P Siegal
Apr 12, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J Le PenduM Clément
Mar 28, 2013·TheScientificWorldJournal·Fumiko TaniuchiKojiro Matsumoto
Feb 1, 2007·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Steven E DominoElizabeth A Hurd
Feb 8, 2011·Journal of Experimental & Clinical Cancer Research : CR·Lili GaoMasao Iwamori
Dec 17, 2011·International Journal of Molecular Sciences·Fan ZhangMasao Iwamori
Apr 17, 2014·Breast Cancer Research and Treatment·Karin Milde-LangoschVolkmar Müller
Nov 17, 2015·Biomolecules·Joelle D Sacks, Maria V Barbolina
Jun 23, 2007·International Journal of Cancer. Journal International Du Cancer·Sylvie MathieuAssou El-Battari
May 16, 2006·The International Journal of Biochemistry & Cell Biology·Jérôme BusserollesMaría José Alcaraz
Oct 7, 2015·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Almudena Fernández-BrieraEmilio Gil-Martín
Nov 6, 2002·Japanese Journal of Cancer Research : Gann·Kyoko TakeharaMasao Iwamori
May 8, 2000·International Journal of Cancer. Journal International Du Cancer·S MarionneauJ Le Pendu
Mar 1, 2010·Oncology Letters·L Muinelo-RomayA Fernández-Briera
Mar 12, 2019·Cell Death Discovery·Tai-Yu LaiAlice L Yu
Feb 9, 2018·Oncotarget·Ninon VeryIkram El Yazidi-Belkoura

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis