PMID: 9641324Jun 26, 1998Paper

Alpha1A-adrenergic receptors mediate vasoconstriction of the isolated spiral modiolar artery in vitro

Hearing Research
D D GruberP Wangemann

Abstract

Several lines of evidence suggest that cochlear blood flow is under the control of the sympathetic nervous system and that this control is mediated via alpha-adrenergic receptors. The goal of the present study was to determine whether alpha-adrenergic receptors mediate vasoconstriction of the spiral modiolar artery and, if so, to determine which subtype dominates this response. Vascular diameter was measured with video microscopy in the isolated superfused spiral modiolar artery in vitro. The diameter of the spiral modiolar artery under control conditions was 61 +/- 2 microm (n = 60). Spontaneous vasomotion was observed in most specimens. Addition of norepinephrine to the superfusate caused a phasic vasoconstriction and an increase in the amplitude of vasomotion. These effects were limited to the vicinity of arteriolar branch points of the spiral modiolar artery. Norepinephrine-induced vasoconstriction occurred with EC50 of (1.9 +/- 0.4) x 10(-5) M (n = 44) and the vascular diameter was maximally reduced by a factor of 0.87 +/- 0.01 (n = 29). Neither the phasic nature nor the EC50 of the norepinephrine-induced vasoconstrictions was altered in the presence of the beta2-adrenergic receptor antagonist 10(-5) M ICI118551 or the nit...Continue Reading

References

Jan 1, 1978·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·E Hultcrantz, C Angelborg
Apr 1, 1992·Archives of Otolaryngology--head & Neck Surgery·H C PillsburyJ Prazma
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L F AllenS Cotecchia
Aug 1, 1991·Circulation Research·K A OhlsénJ M Miller
Apr 1, 1990·Archives of Otolaryngology--head & Neck Surgery·V N CarrascoH C Pillsbury
Oct 1, 1990·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·P B BrechtelsbauerH C Pillsbury
Dec 5, 1989·European Journal of Pharmacology·P J PauwelsP A Janssen
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S CotecchiaB K Kobilka
Jul 7, 1988·European Journal of Pharmacology·G GrossC Rugevics
Jan 16, 1995·European Journal of Pharmacology·A S GoetzD L Saussy
Nov 1, 1994·The Journal of Physiology·E A LaurikainenP J Robinson
May 15, 1994·The Journal of Physiology·E VanBavel, M J Mulvany
Sep 1, 1993·Microvascular Research·M D Frame, I H Sarelius
Jan 1, 1993·Hearing Research·E A LaurikainenA L Nuttall
May 1, 1993·The Annals of Otology, Rhinology, and Laryngology·T RenA L Nuttall
Jul 1, 1995·British Journal of Pharmacology·I MarshallC R Chapple
May 1, 1996·British Journal of Pharmacology·P H Van der GraafJ W Black
Sep 1, 1996·Acta Oto-laryngologica·S Y LiuB G Shivapuja
Apr 1, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·M YangM C Michel

❮ Previous
Next ❯

Citations

Dec 14, 2004·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shusheng GongQing Chang
Sep 25, 2003·Neuroscience and Biobehavioral Reviews·K C Horner
Sep 3, 2002·Hearing Research·Hideaki HoshijimaHiroshi Takenaka
Nov 6, 2003·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Krzysztof MorawskiBrenda L Lonsbury-Martin
Nov 22, 2011·Hearing Research·Kelly M WittMargaret A Scofield
Aug 12, 2009·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Dan HassonBarbara Canlon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.