Alpha1B-adrenoceptors mediate adrenergically-induced renal vasoconstrictions in rats with renal impairment

Acta Pharmacologica Sinica
Md Abdul Hye KhanEdward J Johns

Abstract

This study examined whether alpha1B-adrenoceptors are involved in mediating adrenergically-induced renal vasoconstrictor responses in rats with pathophysiological and normal physiological states. Male Wistar Kyoto and spontaneously hypertensive rats were induced with acute renal failure or experimental early diabetic nephropathy by cisplatin or streptozotocin, respectively. Cisplatin-induced renal failure was confirmed by impaired renal function and pronounced tubular damage. Experimental early diabetic nephropathy was confirmed by hyperglycemia, changes in physiological parameters, and renal function. The hemodynamic study was conducted on anesthetized rats after 7 d of cisplatin (renal failure) and 4 weeks of streptozotocin (experimental early diabetic nephropathy). In the rats with renal failure and experimental early diabetic nephropathy, there were marked reductions in their baseline renal blood flow (P<0.01). The baseline mean arterial blood pressure was either unaltered or lower (all P>0.05) in the renal failure and experimental early diabetic nephropathy rats, respectively, as compared to their non-renal failure and non-diabetic nephropathy controls. In the rats with renal impairment, chloroethylclonidine caused either ...Continue Reading

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Citations

Oct 1, 2010·European Journal of Nutrition·Mohammed H AbdullaEdward J Johns
Jan 28, 2012·Journal of Physiology and Biochemistry·Mohammed H AbdullaEdward J Johns
Jul 8, 2011·The British Journal of Nutrition·Mohammed H AbdullaHassaan A Rathore
Aug 16, 2011·Critical Reviews in Toxicology·Penélope D Sánchez-GonzálezAna I Morales
Aug 10, 2013·The Journal of Pharmacy and Pharmacology·Xihua YangXihua Bai

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