Alpha2-adrenoceptor antagonists enhance responses of dorsal horn neurones to formalin induced inflammation

European Journal of Pharmacology
G M GreenAnthony H Dickenson

Abstract

Intrathecally applied alpha2-adrenoceptor antagonists atipamezole, idazoxan and yohimbine had no significant effect on any neuronal response in normal animals. In contrast, all three antagonists (100 microg) significantly increased the area under the curve of the total response to formalin, especially the second phase. Our results suggest the alpha2-adrenoceptor-mediated noradrenergic inhibitory system in the spinal cord is dormant under normal conditions, but controls both the magnitude and duration of the neuronal responses to subcutaneous injection of formalin.

Citations

Jun 29, 2004·Anesthesiology·Heikki MansikkaAntti Pertovaara
Mar 30, 2016·Pain·Kirsty Bannister, Anthony H Dickenson
Apr 5, 2016·Current Opinion in Supportive and Palliative Care·Kirsty Bannister, Anthony H Dickenson
Apr 8, 2017·The Journal of Physiology·Kirsty Bannister, A H Dickenson
Jun 14, 2013·Journal of Psychopharmacology·Elemer Szabadi
Dec 7, 2010·The American Journal of Hospice & Palliative Care·Eric Prommer
Mar 27, 2019·Behavioral and Brain Functions : BBF·Patrícia Sanae Souza LopesRosana Lima Pagano
Mar 19, 2013·European Journal of Pharmacology·Antti Pertovaara
May 30, 2002·Progress in Neurobiology·Mark J Millan
Oct 13, 2006·Progress in Neurobiology·Antti Pertovaara
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Rie SuzukiAnthony H Dickenson

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