Alpha2-adrenoceptor modulation of long-term potentiation elicited in vivo in rat occipital cortex

Brain Research
Mauricio MondacaRubén Soto-Moyano

Abstract

Pretreatment with the alpha(2)-adrenoceptor agonist clonidine (31.25, 62.5, or 125 microg/kg, i.p.) dose-dependently reduced long-term potentiation (LTP) elicited in vivo in the occipital cortex of anesthetized rats, whereas pretreatment with the alpha(2)-adrenoceptor antagonist yohimbine (0.133, 0.4, or 1.2 mg/kg, i.p.) increased neocortical LTP in a dose-dependent fashion. These effects could be related to the reported disruptive and facilitatory actions induced on memory formation by pretreatment with alpha(2)-adrenoceptor agonists and antagonists, respectively.

References

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Citations

Apr 23, 2013·European Journal of Pharmacology·Majid Jafari-SabetMohammad-Amin Khodadadnejad
Jun 1, 2010·Brain Research Bulletin·Osvaldo FloresAlejandro Hernández
Mar 29, 2008·The European Journal of Neuroscience·Min-Ching Kuo, Hans C Dringenberg
Dec 25, 2007·Anesthesiology·Isao TakamatsuMasayuki Sekiguchi

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