alpha2-Macroglobulin (alpha2M) has been identified on the luminal surface of endothelial cells in sections of normal human arteries, veins, and lymphatics by the indirect immunofluorescent technique. The specificity of the immunofluorescent reaction was confirmed by immunoabsorption studies. Prior absorption of the anti-alpha2M antiserum by purified alpha2M at equivalence completely inhibited endothelial surface as well as hepatic parenchymal cell staining. Endothelial cells in blood vessels were not stained when sections were treated with rabbit antisera toward alpha1-antitrypsin, antithrombin III, IgG, IgA, IgM, C3, or fibrinogen. The location of alpha2M at the surface of the vessel wall suggests that this protease inhibitor may protect the vascular endothelium from potentially injurious intravascular proteases.
Studies on human plasma alpha 2-macroglobulin-enzyme interactions. Evidence for proteolytic modification of the subunit chain structure
Soluble mediators of injury of the microvasculature; Hageman factor and the kinin forming, intrinsic clotting and the fibrinolytic systems
Development of gamma G, gamma A, gamma M, beta IC-beta IA, C 1 esterase inhibitor, ceruloplasmin, transferrin, hemopexin, haptoglobin, fibrinogen, plasminogen, alpha 1-antitrypsin, orosomucoid, beta-lipoprotein, alpha 2-macroglobulin, and prealbumin in the human conceptus
Sectioning at room temperature of unfixed tissues, frozen in a gelatin matrix, for immunohistologic procedures
Different phenotypes of cultured microvessel endothelial cells obtained from bovine corpus luteum. Study by light microscopy and by scanning electron microscopy (SEM)
On the prevention of haematogenous tumor metastases rats. The role of the proteinase inhibitor "Trasylol"
Stimulation of cyclic AMP production by vasoactive agents in cultured bovine aortic and pulmonary artery endothelial cells
Alpha 2-macroglobulin and generation of oxygen radicals by granulocytes: potential role in prevention and treatment of reperfusion injury
Babesia bovis (Argentina): studies on the composition and location of antigen associated with infected erythrocytes
Synthesis and secretion of alpha-2-macroglobulin by cultured adherent lung cells. Comparison with cell strains derived from other tissues
New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model
Immunohistochemical techniques and their applications in the histopathology of the respiratory system
The adherence to human endothelium and plastic of neutrophils from psoriatic patients, and the effects of psoriatic patients' sera on normal neutrophils
Income, social stratification, class, and private health insurance: a study of the Baltimore metropolitan area
Lanthanum staining of coronary microvascular endothelium: effects of ischemia reperfusion, propranolol, and atenolol
Activation of blood clotting in patients with systemic lupus erythematosus. Relationship to disease activity
S100A8, S100A9 and the S100A8/A9 heterodimer complex specifically bind to human endothelial cells: identification and characterization of ligands for the myeloid-related proteins S100A9 and S100A8/A9 on human dermal microvascular endothelial cell line-1 cells
Determinants of fertility in urban and rural Kenya: estimates and a simulation of the impact of education policy
Variant endothelial cells. Fibronectin as a transducer of signals for migration and neovascularisation
Endothelial cells modify the costimulatory capacity of transmigrating leukocytes and promote CD28-mediated CD4(+) T cell alloactivation
COVID-19-associated coagulopathy - Hypothesis: Are Children protected due to enhanced thrombin inhibition by higher α2 -Macroglobulin (α2-M)?
CSF & Lymphatic System
This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.