alpha2,3-sialyltransferase mRNA and alpha2,3-linked glycoprotein sialylation are increased in malignant gliomas

Brain Research
H YamamotoJ R Moskal

Abstract

CMP-NeuAc: Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase (alpha2,3-ST) mRNA was expressed in human glioma specimens, human fetal astrocytes, and a panel of brain tumor cell lines. Maackia amurensis agglutinin staining revealed the presence of alpha2,3-linked sialic acids on glioma cell surfaces and extracellular matrices whereas normal human adult astrocytes were negative. Increased expression of alpha2,3-linked glycoprotein sialylation may play a role in glial tumorigenesis.

References

Jan 1, 1990·The International Journal of Biochemistry·P ReboulP Louisot
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·L WarrenC A Buck
Jul 15, 1983·International Journal of Cancer. Journal International Du Cancer·J A WerkmeisterJ C Roder

❮ Previous
Next ❯

Citations

Dec 6, 2007·Journal of Neurochemistry·Roger A KroesJoseph R Moskal
Dec 26, 2007·Glycoconjugate Journal·Manisha H ShahPrabhudas S Patel
Oct 17, 2009·Expert Review of Neurotherapeutics·Joseph R MoskalGlyn Dawson
Dec 16, 2016·Glycoconjugate Journal·Bhairavi N Vajaria, Prabhudas S Patel
Oct 17, 2014·Glycoconjugate Journal·Bhairavi N VajariaPrabhudas S Patel
Mar 19, 1999·Biochemical and Biophysical Research Communications·C J DimitroffR J Bernacki
Jun 12, 2003·Gynecologic Oncology·Peng Hui WangChiou Chung Yuan
Sep 26, 2015·Journal of Medicinal Chemistry·Wenming LiXin-Shan Ye
Oct 6, 2017·ACS Chemical Neuroscience·Lucas VeillonYehia Mechref

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.