PMID: 15220790Jun 29, 2004Paper

Alpha(2A) adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia

Anesthesiology
Heikki MansikkaAntti Pertovaara

Abstract

Studies on receptor knockout mice have so far shown that of the three alpha2-adrenoceptor subtypes, the alpha(2A) adrenoceptor has a major role in mediating the powerful central analgesia induced by synthetic alpha2-adrenoceptor agonists. However, because a knockout of the gene for the alpha(2A) adrenoceptor has produced only little if any change in the pain sensitivity of control, nerve-injured, or inflamed animals, it has not been clear whether activation of alpha(2A)-adrenoceptors by endogenous ligands has a significant pain regulatory role. The authors assessed spontaneous pain behavior and mechanical hypersensitivity induced by administration of capsaicin in the colon or paw of alpha(2A)-adrenoceptor knockout mice versus their wild-type controls. Enhanced pain hypersensitivity was observed in alpha(2A)-adrenoceptor knockout mice 20 min or more after administration of capsaicin, but before, hypersensitivity and spontaneous pain were of equal magnitude in alpha(2A)-adrenoceptor knockout and wild-type mice. When wild-type mice were pretreated with an alpha2-adrenoceptor antagonist, capsaicin-induced pain hypersensitivity increased to a level equal to that in alpha(2A)-adrenoceptor knockout mice. Capsaicin-induced hypersensiti...Continue Reading

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May 20, 2003·European Journal of Pharmacology·Janne LähdesmäkiHeikki Mansikka

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Citations

Jan 21, 2011·The Journal of Pharmacology and Experimental Therapeutics·Shao-Rui ChenHui-Lin Pan
Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Patrick W HoworthAnthony E Pickering
Apr 5, 2008·The Journal of Pain : Official Journal of the American Pain Society·Xiao-Jun ZhangZhao-Xiang Bian
Oct 26, 2007·Pharmacology & Therapeutics·Hui-Lin PanDe-Pei Li
Aug 29, 2012·Fundamental & Clinical Pharmacology·Rafael A S RangelMarcos A Lessa
Oct 10, 2006·European Journal of Pharmacology·Hong Wei, Antti Pertovaara
Oct 13, 2006·Progress in Neurobiology·Antti Pertovaara
Jul 4, 2006·The Journal of Pain : Official Journal of the American Pain Society·Dae-Hyun RohJang-Hern Lee
Mar 19, 2013·European Journal of Pharmacology·Antti Pertovaara
Jan 1, 2012·Pharmaceuticals·Kelly A BergArmen N Akopian
Jan 27, 2017·Translational Neuroscience·Ruiqin LiWeifu Lei

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