PMID: 9174250May 20, 1997Paper

Alpha2B adrenoceptor mRNA expression during rat brain development

Brain Research. Developmental Brain Research
U H Winzer-Serhan, F M Leslie

Abstract

The expression of alpha2B adrenoceptor mRNA in developing and adult rat brain was examined, using in situ hybridization with S-labeled riboprobes. In the adult we have detected more widespread expression than previously reported, with moderate to strong hybridization signals in the fundus striati, olfactory tubercles, septum, thalamus and Purkinje cells of the cerebellum. In addition, there was low expression in the endopiriform nucleus, claustrum, cortex, caudate-putamen and spinal trigeminal nucleus of the brain stem. During embryonic development, there was intense, transient mRNA expression in the developing vascular plexus and vasculature which disappeared by birth. In most brain areas which exhibit mRNA expression in the adult, expression started during late embryonic development; with the exception of the thalamus, where expression was differentially regulated in sensory and non-sensory thalamic nuclei starting at the end of the first postnatal week. In addition, there was transiently upregulated expression in the caudate-putamen and cerebellar Purkinje cells during late embryonic and early postnatal development, respectively. This transient expression correlates with the time of neuronal migration and differentiation in ...Continue Reading

References

Feb 1, 1992·Pharmacology, Biochemistry, and Behavior·J K WamsleyD B Bylund
Jun 1, 1991·Brain Research. Molecular Brain Research·D W Zeng, K R Lynch
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D W ZengK R Lynch
May 9, 1980·Science·S J PeroutkaS H Snyder
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S I HarikS P Banerjee
Apr 1, 1995·Neuropharmacology·L Hein, B K Kobilka
Jun 1, 1993·Hypertension·D E HandyH Gavras
Jan 1, 1994·Brain Research. Molecular Brain Research·M ScheininR T Fremeau
Feb 22, 1993·The Journal of Comparative Neurology·A P NicholasT Hökfelt
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S A Bayer

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Citations

Sep 21, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Guey-Shin WangAlice Chien Chang
Jan 18, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jyotsna Pandey, Douglas L Wendell
Mar 19, 1999·European Journal of Pharmacology·A M McNeillS P Duckles
Mar 8, 2002·Brain Research. Developmental Brain Research·Yi HuangJohn W Regan
Mar 29, 2001·Autonomic Neuroscience : Basic & Clinical·J K Phillips, J Lipski
Jan 12, 2002·British Journal of Pharmacology·Peregrine B OsborneMacDonald J Christie
Feb 17, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·William MarrsJ David Jentsch
Jun 26, 2002·The European Journal of Neuroscience·Jouni A Ihalainen, Heikki Tanila
Jul 11, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Y ChenC Y Chai
Jul 13, 2002·Pharmacology & Therapeutics·David Weinshenker, Patricia Szot
Jul 19, 2012·The European Journal of Neuroscience·Orbicia RiccioAlexandre Dayer
Sep 8, 2004·Brain Research. Developmental Brain Research·Marisa L KreiderTheodore A Slotkin
Jul 21, 2006·Brain Research·Jeff D SandersL Charles Murrin
Oct 23, 1997·The Journal of Comparative Neurology·U H Winzer-Serhan, F M Leslie
Apr 24, 2001·Psychological Bulletin·R Kurzban, M R Leary
Oct 28, 2005·Journal of Neurophysiology·Moritoshi Hirono, Kunihiko Obata
Feb 18, 1999·Journal of Neurobiology·U H Winzer-Serhan, F M Leslie
Jul 6, 2000·European Journal of Pharmacology·H K HappeL C Murrin
Jul 13, 2002·European Journal of Cell Biology·Stavros TaravirasChristodoulos Flordellis

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