alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation.

Neuropharmacology
Mariana Vargas-CaballeroO Paulsen

Abstract

GABA(A) receptors that contain the alpha5 subunit (alpha5GABA(A)Rs) are highly expressed in the hippocampus, and have been implicated in learning and memory processes. They generate a tonic form of inhibition that regulates neuronal excitability. Recently it was shown that alpha5GABA(A)Rs also contribute to slow phasic inhibition of CA1 pyramidal neurons following local stimulation in the stratum lacunosum moleculare. However, it is unknown whether alpha5GABA(A)Rs can also be recruited indirectly by stimulation of Schaffer collaterals. Here, we studied GABAergic currents evoked by stimulation in the stratum radiatum of CA1 in the presence and absence of CNQX to block AMPA receptor-mediated excitation. We tested their sensitivity to gabazine and two drugs acting at the benzodiazepine site of alpha1/alpha2/alpha3 or alpha5GABA(A)Rs (400 nM zolpidem and 20 nM L-655,708, respectively). IPSCs evoked by stimulation in the stratum radiatum in the presence of CNQX were potentiated by zolpidem, blocked by 1 muM gabazine and were relatively insensitive to L-655,708 consistent with the lack of alpha5GABA(A)Rs. In contrast, IPSCs evoked by stimulation of Schaffer collaterals had a significant gabazine-insensitive component. This component ...Continue Reading

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Citations

Jun 26, 2012·Psychopharmacology·Karina A ZaninRoberto Frussa-Filho
Apr 23, 2013·European Journal of Pharmacology·Majid Jafari-SabetMohammad-Amin Khodadadnejad
Aug 30, 2012·The Journal of Physiology·Mirosława MańkoMarco Capogna
Dec 15, 2010·Neuropharmacology·Costas Papatheodoropoulos, Efthymios Koniaris
Aug 1, 2012·PloS One·Ora OhanaKevan A C Martin
Jul 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Noëlie S CaylaEdward J Bertaccini
Mar 20, 2020·Cerebral Cortex·Chrysia M PegasiouMariana Vargas-Caballero
Aug 10, 2019·Frontiers in Molecular Neuroscience·Tija C Jacob

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Methods Mentioned

BETA
genetic modifications

Software Mentioned

Matlab
Ginj

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