alpha(6) Integrin is the main receptor of human papillomavirus type 16 VLP

Biochemical and Biophysical Research Communications
C S YoonS W Cheong

Abstract

The present study was performed to determine the specific receptor of type HPV-16 using recombinant human papillomavirus-like particle (HPV-16 L1-VLP). The expression levels of alpha(6), beta(1), and beta(4) integrins were determined and compared with the amount of HPV-VLP binding in ten cell lines by flow cytometry. Our results show that the amount of VLP binding and the expression level of alpha(6) integrin are correlated, which was confirmed by an inhibition experiment using antibodies and by immunocytochemistry. Both the expression level of alpha(6) integrin and the amount of HPV-VLP binding were high in cervical cancer cell lines, as the type HPV-16 is the main cause of cervical cancer. The degree of binding of HPV-VLP matched the alpha(6) integrin expression level in cell lines but was not correlated with beta(1) and beta(4) levels, which suggests that alpha(6) integrin is the main receptor of HPV type 16.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Mar 18, 1992·Journal of the National Cancer Institute·M H Schiffman
Mar 27, 1992·Science·J M BergelsonR W Finberg
Nov 22, 1991·Science·H zur Hausen
Feb 1, 1991·Trends in Biochemical Sciences·B Sugden
Nov 1, 1989·Journal of Virology·E M de Villiers
Nov 1, 1987·Journal of Virology·P M LarsenS J Fey
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L GissmannH zur Hausen
Nov 1, 1994·Journal of Virology·R B RodenJ T Schiller
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·D R LowyJ T Schiller
Mar 1, 1997·Journal of Virology·M EvanderN A McMillan
Jan 1, 1997·Journal of Cancer Research and Clinical Oncology·N KoikeT Watanabe
Oct 23, 1997·Current Opinion in Cell Biology·F G Giancotti
Jan 13, 1998·Biochemical and Biophysical Research Communications·K NishidaS Kitazawa
Jul 24, 1998·Cellular and Molecular Life Sciences : CMLS·C M Longhurst, L K Jennings
Jul 24, 1998·Cellular and Molecular Life Sciences : CMLS·P Clezardin

❮ Previous
Next ❯

Citations

Jan 11, 2013·Journal of Virology·Konstanze D SchefferLuise Florin
May 14, 2005·Journal of Virology·Nicole A PattersonMichelle A Ozbun
May 2, 2009·Journal of Dental Research·M J Conway, C Meyers
Apr 11, 2013·BMC Cancer·Georgia SchäferM Iqbal Parker
Jan 22, 2010·Virology Journal·Caroline A J HorvathJohn-Paul J Bogers
Jan 7, 2010·Virology Journal·Tan Letian, Zhang Tianyu
May 6, 2011·Theranostics·Gang Niu, Xiaoyuan Chen
Feb 21, 2014·Viruses·Konstanze D SchefferLuise Florin
Sep 14, 2012·Medical Microbiology and Immunology·Luise FlorinGilles A Spoden
Jun 2, 2005·Der Pathologe·M J TrunkM von Knebel Doeberitz
Jul 2, 2005·Expert Opinion on Emerging Drugs·F X Wilson
Dec 15, 2010·The Breast : Official Journal of the European Society of Mastology·Roberto Herrera-GoepfertVíctor Manuel Pérez-Sánchez
Sep 1, 2015·Archives of Virology·Hosni A M HusseinShaw M Akula
Dec 8, 2004·Gynecologic Oncology·Stephen A ContagEric S Calhoun
Oct 26, 2005·Biosensors & Bioelectronics·Z DuL Gollahon
Sep 29, 2004·Antiviral Research·Peter DrobniMagnus Evander
Mar 10, 2017·Cell Biology and Toxicology·Prathyusha BagamSanjay Batra
Aug 12, 2003·The Journal of Biological Chemistry·Maria J CalzadaDavid D Roberts
Aug 8, 2015·Viruses·Jennifer Biryukov, Craig Meyers
Apr 15, 2017·Biochemical Society Transactions·Laura A FastLuise Florin
Oct 7, 2006·Biotechnology Progress·Swapnil P WankhedeLauren Gollahon
Jul 30, 2010·The Laryngoscope·Clint T AllenBrian Nussenbaum
Oct 5, 2010·Nature Reviews. Drug Discovery·Dermot CoxNiamh Moran
Nov 1, 2013·Thoracic Cancer·Nan-Yung HsuYa-Wen Cheng
Jul 15, 2020·Transboundary and Emerging Diseases·Faezeh Almasi, Fatemeh Mohammadipanah
May 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Stephen DiGiuseppeMartin J Sapp

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.