AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors

Toxicon : Official Journal of the International Society on Toxinology
Russell W TeichertBaldomero M Olivera

Abstract

The venoms of cone snails are rich in multiply disulfide-crosslinked peptides, the conotoxins. Conotoxins are grouped into families on the basis of shared cysteine patterns and homologous molecular targets. For example, both the kappaA- and alphaA-conotoxin families share the same Class IV Cys pattern (-CC-C-C-C-C-), but differ in their molecular targets. The kappaA-conotoxins are excitatory toxins that purportedly block potassium channels, while the alphaA-conotoxins are paralytic conotoxins that inhibit nicotinic acetylcholine receptors (nAChRs). In this work, we describe the isolation and characterization of a novel Conus peptide from venom milked from Hawaiian specimens of Conus obscurus. This peptide shares the Class IV Cys pattern but differs from both previously characterized alphaA- and kappaA-conotoxins in the spacing of amino acids between Cys resides. However, the peptide is similar to previously characterized alphaA-conotoxins in its paralytic effects on fish and its antagonist activity on the neuromuscular nAChR. Unexpectedly, the peptide differs in its disulfide bonding from alphaA-conotoxin PIVA. We have named this unique peptide alphaA-conotoxin OIVA, and we consider it the defining member of a subfamily of alph...Continue Reading

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Citations

May 22, 2009·Journal of Proteomics·Daniel BiassReto Stöcklin
Dec 19, 2014·Marine Drugs·Samuel D Robinson, Raymond S Norton
Aug 10, 2010·Peptides·Can PengChengwu Chi
Mar 10, 2010·Toxicon : Official Journal of the International Society on Toxinology·Quentin KaasDavid J Craik
Mar 9, 2010·Toxicon : Official Journal of the International Society on Toxinology·Sébastien DutertrePhilippe Favreau
Apr 28, 2009·Toxicon : Official Journal of the International Society on Toxinology·S KaufersteinD Mebs
Nov 23, 2006·Toxicon : Official Journal of the International Society on Toxinology·Russell W TeichertBaldomero M Olivera
Feb 15, 2005·Analytical Biochemistry·Jon-Paul BinghamEdward G Moczydlowski
Nov 25, 2004·Current Opinion in Biotechnology·Knut AdermannWolf-Georg Forssmann
Oct 6, 2009·Chemico-biological Interactions·Jon-Paul BinghamZachary L Bergeron
Sep 6, 2006·Toxicon : Official Journal of the International Society on Toxinology·Raymond S Norton, Baldomero M Olivera
Sep 19, 2006·Toxicon : Official Journal of the International Society on Toxinology·Bruce G LivettZeinab Khalil
Aug 15, 2006·The Journal of Biological Chemistry·Baldomero M Olivera
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Nov 2, 2017·Biochemistry·Carla A OmagaGisela P Concepcion

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