Alpha/beta (α/β) ratio for prostate cancer derived from external beam radiotherapy and brachytherapy boost

The British Journal of Radiology
Philip S BoonstraRafał Suwiński

Abstract

There is disagreement regarding the value of the α/β ratio for prostate cancer. Androgen deprivation therapy (ADT) may dominate the effects of dose fractionation on prostate-specific antigen (PSA) response and confound estimates of the α/β ratio. We estimate this ratio from combined data on external beam radiation therapy (EBRT) and brachytherapy (BT)-treated patients, providing a range of doses per fraction, while accounting for the effects of ADT. We analyse data on 289 patients with local prostate cancer treated with EBRT (2 Gy per fraction) or EBRT plus one or two BT boosts of 10 Gy each. The timing of ADT was heterogeneous. We develop statistical models to estimate the α/β ratio based upon PSA measurements at 1 year as a surrogate for the surviving fraction of cancer cells as well as combined biochemical + clinical recurrence-free survival (bcRFS), controlling for ADT. For the PSA-based end point, the α/β ratio estimate is 7.7 Gy [95% confidence interval (CI): 4.1 to 12.5]. Based on the bcRFS end point, the estimate is 18.0 Gy (95% CI: 8.2 to ∞). Our model-based estimates of the α/β ratio, which account for the effects of ADT and other important confounders, are higher than some previous estimates. Although dose inhomogene...Continue Reading

References

Apr 7, 1999·International Journal of Radiation Oncology, Biology, Physics·D J Brenner, E J Hall
Jun 10, 2000·International Journal of Radiation Oncology, Biology, Physics·C R King, C S Mayo
Dec 31, 2002·International Journal of Radiation Oncology, Biology, Physics·Jian Z WangX Allen Li
Sep 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Alan E NahumJ Donald Chapman
Jul 2, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Søren M Bentzen, Mark A Ritter
Apr 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Scott G WilliamsHoward Sandler
May 15, 2007·International Journal of Radiation Oncology, Biology, Physics·Rafal SuwinskiJerzy Wydmanski
Jan 6, 2010·International Journal of Radiation Oncology, Biology, Physics·Giorgio ArcangeliLidia Strigari
Jun 19, 2010·International Journal of Radiation Oncology, Biology, Physics·Richard ShafferVitali Moiseenko
Aug 21, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Philippe NickersEric Lartigau
Aug 30, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Riccardo ValdagniClaudio Fiorino
Feb 22, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter J HoskinLinda Bryant
Apr 28, 2012·International Journal of Radiation Oncology, Biology, Physics·Stefano ArcangeliGiorgio Arcangeli
Jun 2, 2012·International Journal of Radiation Oncology, Biology, Physics·Ivan R Vogelius, Søren M Bentzen
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alan PollackMark K Buyyounouski
Jan 15, 2014·International Journal of Radiation Oncology, Biology, Physics·Hossein AfsharpourLuc Beaulieu
Feb 25, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Stephen A RobertsJolyon H Hendry
Apr 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark J Brenner, Irving D Kaplan
Apr 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ivan R Vogelius, Søren M Bentzen
Apr 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alan PollackMark K Buyyounouski

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Citations

Apr 19, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Ciro FranzeseMarta Scorsetti
Aug 3, 2020·International Journal of Radiation Oncology, Biology, Physics·Marco MarcelloMartin A Ebert

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