AlphaCor keratoprosthesis: a novel approach to minimize the risks of long-term postoperative complications

Cornea
Vanessa NgakengFrancis W Price

Abstract

To describe clinical outcomes of patients who underwent implantation of the AlphaCor keratoprosthesis, without the second stage of the procedure, in which the central anterior layer of the corneal stromal pocket is excised to expose the keratoprosthesis optic to the exterior of the eye. Outcomes of 6 consecutive cases of AlphaCor implantation without the second stage of the procedure were retrospectively reviewed. The cases were performed at 1 tertiary referral center between February 2005 and December 2006. Each of the 6 treated eyes had experienced failure of 2-5 human donor grafts before AlphaCor implantation. With a mean follow-up of 22 months (range, 14-38 months), all devices remained in situ at time of review. All patients had decreased pain compared with what they experienced preoperatively, and preoperative bullous keratopathy resolved after AlphaCor implantation. Two patients developed retroprosthetic membranes. Five patients developed elevated intraocular pressure requiring additional medication or surgery in the postoperative course, but 4 of them had preexisting glaucoma. No patients developed breakdown of the ocular surface, increased ocular surface disease, stromal melting, aqueous leakage, infection, or extrusio...Continue Reading

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Citations

Mar 13, 2014·Acta Biomaterialia·Enas HassanSheila MacNeil
Mar 10, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Jun XiangJianjiang Xu
Mar 15, 2013·Journal français d'ophtalmologie·E TrichetL Hoffart
Sep 16, 2010·Veterinary Ophthalmology·Pierre-François IsardAlain Regnier
Feb 13, 2010·Veterinary Ophthalmology·Ingrid AllgoewerSunita Agarwal
Apr 22, 2015·Survey of Ophthalmology·Michael A KlufasSzilárd Kiss
Jul 28, 2009·Acta Biomaterialia·Chao DengMay Griffith
Sep 10, 2014·European Journal of Ophthalmology·Louis HoffartFrédéric Matonti

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