PMID: 19145507Jan 16, 2009Paper

Alphastatin inhibits tumor angiogenesis in nude mice bearing human gastric cancer xenografts

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
Tao Li, Ling Chen

Abstract

To explore the effect and mechanism of alphastatin on tumor angiogenesis in nude mice bearing human gastric cancer xenografts. Nude mice were injected subcutaneously with matrigel matrix into matrigel plug. The effect of alphastatin on neovasculature inside Matrigel plug was observed. Human gastric cancer cells (BGC823) were injected subcutaneously in nude mice. After intraperitoneal injection of PBS or alphastatin,tumor volume, weight and microvascular density were analyzed. Sphingosine kinase(SPK) activity assay was used to evaluate the effect of alphastatin on tumor endothelial cells. In vivo, alphastatin was sufficiently potent to suppress nude mice neovascularization. Daily administration of alphastatin produced significant tumor growth suppression [tumor volume:(612.65+/-23.45) microm(3),(1145.96+/-29.89) microm(3) vs(1771+/-31.05) microm(3) (P<0.05), tumor weight: (0.31+/-0.03) g, (0.12+/-0.02) g vs (0.67+/-0.02) g (P<0.05)]. Immunohistochemical studies of tumor tissues revealed decreased microvessel density in alphastatin-treated animals as compared with controls. Alphastatin significantly inhibited tumor endothelial cells SPK activity. Alphastatin shows potent antiangiogenic properties in nude mice,which might be close...Continue Reading

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