Alphavirus expression vectors and their use as recombinant vaccines: a minireview

Gene
I TubulekasP Liljeström

Abstract

Alphavirus vectors have become widely used in basic research to study the structure and function of proteins and for protein production purposes. Development of a variety of vectors has made it possible to deliver foreign sequences as naked RNA or DNA, or as suicide virus particles produced using helper vector strategies. Preliminary reports also suggest that these vectors may be useful for in vivo applications where transient, high-level protein expression is desired, such as recombinant vaccines. The initial studies have already shown that alphavirus vaccines can induce strong humoral and cellular immune responses with good immunological memory and protective effects.

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S D LondonC M Rice
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S HahnC M Rice
Aug 1, 1991·Journal of Virology·B G Weiss, S Schlesinger
Jan 1, 1994·Methods in Cell Biology·R C PiperD E James
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·X ZhouM Jondal
Jan 1, 1993·Trends in Biotechnology·S Schlesinger
Oct 1, 1994·Current Opinion in Biotechnology·P Liljeström
Sep 1, 1994·Microbiological Reviews·J H Strauss, E G Strauss
Nov 1, 1993·Journal of Virology·P J BredenbeekS Schlesinger
Sep 1, 1995·Human Gene Therapy·H HerweijerJ A Wolff
Apr 1, 1996·Trends in Biotechnology·P BerglundP Liljeström

❮ Previous
Next ❯

Citations

Sep 6, 2000·Veterinary Immunology and Immunopathology·L A Babiuk van Drunnen Littel-van den Hur
Sep 21, 2000·Immunology Letters·M C BonnetP Moingeon
Mar 21, 2001·Vaccine·S van Drunen Littel-van den HurkL A Babiuk
Dec 2, 1999·Vaccine·W W LeitnerN P Restifo
Jan 26, 2000·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·M GirardC Chanel
Jun 13, 1998·Nature Biotechnology·P BerglundP Liljeström
May 29, 2002·Hybridoma and Hybridomics·Stanley A Plotkin
Oct 21, 2011·Journal of Virology·Christy K JurgensRobert E Johnston
Jun 3, 2000·Annual Review of Immunology·S GurunathanR A Seder
Apr 6, 2007·Expert Review of Vaccines·Matthias LinigerHussein Y Naim
Aug 18, 2006·Vaccine·Shengqiang LiFilip Dubovsky
May 27, 2006·Vaccine·Wolfgang W LeitnerNicholas P Restifo
Apr 17, 2001·Infectious Disease Clinics of North America·S A Plotkin
Apr 11, 2000·Gene Therapy·J J WahlforsR A Morgan
Jul 11, 1998·The Journal of Biological Chemistry·D P DiCiommo, R Bremner
Sep 29, 1999·The Journal of General Virology·G J AtkinsP Liljeström

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.