Alpinetin targets glioma stem cells by suppressing Notch pathway

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Jianpeng WangWeicheng Yao

Abstract

Glioma is among the most common human malignancies with poor prognosis. Glioma stem cells (GSCs) are the culprit of glioma, suggesting that GSCs are potential therapeutic targets. Notch signaling pathway plays a pivotal role for the function of GSCs, implying that suppression of Notch pathway may be an effective strategy for GSC-targeting therapy. In this study, we found that alpinetin, a natural compound, can suppress the proliferation and invasiveness of GSCs and induce apoptosis in GSCs. Immunoblot analysis and luciferase assay revealed that Notch signaling was suppressed by alpinetin. Furthermore, restoration of Notch signaling activity rescued the effect of alpinetin on GSC's function. The anti-tumor activity of alpinetin was further confirmed in an animal model. Collectively, targeting of GSC by alpinetin is an effective strategy for glioma therapy.

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Citations

Jul 6, 2019·Anti-cancer Agents in Medicinal Chemistry·Plabon K DasFarhadul Islam
Jan 10, 2020·Oxidative Medicine and Cellular Longevity·Giorgio AquilaPaola Rizzo
Sep 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jieying QiuZheng Xiang

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