Alpinia oxyphylla-Schisandra chinensis Herb Pair Alleviates Amyloid-β Induced Cognitive Deficits via PI3K/Akt/Gsk-3β/CREB Pathway.

Neuromolecular Medicine
Yu QiYing Jia

Abstract

Alzheimer's disease (AD), one of the most common neurodegenerative diseases, threatens people's health. Based on the theory of traditional Chinese medicine (TCM) efficacy and treatment theory, we first proposed the Alpinia oxyphylla-Schisandra chinensis herb pair (ASHP) for finding a candidate of AD treatment. This study aimed at exploring the effects of ASHP on improving the cognitive function and neurodegeneration, and revealing the possible mechanism. In this study, an amyloid-β (Aβ) induced AD model was established in mice via intracerebroventricular injection. The Y-maze test and Morris water maze test were carried out to observe the behavioral change of mice, which showed that ASHP significantly ameliorated cognitive impairment. In addition, ASHP reduced amyloid-β deposition and downregulated the hyperphosphorylation of tau via immunofluorescence assay and western blot analysis, respectively. Subsequently we focused on the PI3K/Akt pathway that is a classical pathway related to nervous system diseases. It also noticeably ASHP improved the histopathological changes in the hippocampus and cortex. Moreover, it was found that ASHP could upregulate the PI3K/Akt/Gsk-3β/CREB signaling pathway in N2a-SwedAPP cells. Taken together...Continue Reading

References

Sep 7, 2007·The International Journal of Biochemistry & Cell Biology·Peter J CrouchColin L Masters
Jan 27, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·A DesaiM L Tripp
Apr 29, 2009·The Veterinary Journal·Jack Murphy
Feb 26, 2014·Neuropharmacology·Maoping TangZhongdong Qiao
Jun 21, 2014·Biochemical and Biophysical Research Communications·Nie TianTomoyuki Nishizaki
Mar 5, 2015·Journal of Psychopharmacology·Zinaida I StorozhevaRobert D E Sewell
Aug 19, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Pengwei ZhuangHongyan Li
Jul 15, 2016·Journal of Molecular Endocrinology·F AstortC B Cymeryng
Aug 2, 2016·Behavioural Brain Research·Xiao-Wen YuJohn F Disterhoft
Jan 23, 2017·Biochemical and Biophysical Research Communications·Rui ZhengGuo-Li Song
Apr 16, 2017·Neurologic Clinics·John M Ringman
Oct 29, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mengshi WangYing Jia
Nov 4, 2017·Trends in Neurosciences·Carlos A Saura, Jean-René Cardinaux

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
PCR

Software Mentioned

GraphPad Prism
NIH ImageJ

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Related Papers

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
L R Dotson, D R Witmer
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
C R Talley
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
© 2021 Meta ULC. All rights reserved