PMID: 15232333Jul 3, 2004Paper

Alprazolam attenuates the behavioral effects of d-amphetamine in humans

Journal of Clinical Psychopharmacology
Craig R RushPaul E A Glaser

Abstract

The results of preclinical behavioral pharmacology studies suggest that gamma-aminobutyric acidA (GABAA) receptor modulators attenuate the behavioral effects of commonly abused stimulants such as amphetamines and cocaine under a variety of behavioral arrangements including drug discrimination and self-administration. In the present experiment, 6 healthy humans learned to discriminate 15-mg oral D-amphetamine. After acquiring the discrimination (ie, . > or = 80% correct responding on 4 consecutive days), the effects of a range of doses of D-amphetamine (0, 2.5, 5, 10, and 15 mg), alone and following pretreatment with alprazolam (0 and 0.5 mg), a GABAA receptor modulator, were assessed. D-Amphetamine alone functioned as a discriminative stimulus and produced stimulant-like self-reported drug effects (eg, increased scores on a Stimulant-Sensitive Adjective-Rating Scale). These effects were generally a function of dose. Alprazolam alone did not occasion D-amphetamine-like discriminative stimulus effects, nor did it increase ratings of sedation or impair performance. Alprazolam pretreatment significantly attenuated the discriminative stimulus effects of D-amphetamine, and some of the self-reported drug effects. Future human laborato...Continue Reading

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Citations

Feb 25, 2005·Experimental and Clinical Psychopharmacology·William W StoopsCraig R Rush
Jul 1, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joshua A LileCraig R Rush
Jul 22, 2005·The Journal of Pharmacology and Experimental Therapeutics·Andrew C BarrettS Barak Caine
Dec 28, 2010·Neuroscience and Biobehavioral Reviews·Susan Schenk
Sep 15, 2005·Drug and Alcohol Dependence·Margaret HaneyRichard W Foltin
May 23, 2015·Frontiers in Cellular Neuroscience·Dongliang JiaoMin Zhao
Jul 7, 2011·Neurotoxicology·L HondebrinkR H S Westerink
Dec 3, 2014·Drug and Alcohol Dependence·Gudrun HøisethJørg Mørland
Oct 26, 2016·Pharmacology, Biochemistry, and Behavior·Erika PikeCraig R Rush
Oct 22, 2017·The Journal of Pharmacology and Experimental Therapeutics·Scott A SchelpErik B Oleson
Sep 1, 2019·International Journal of Psychiatry in Medicine·Paul A Zarkowski
Sep 22, 2020·International Journal of Psychiatry in Medicine·Paul A ZarkowskiJacob A Groen
Jun 22, 2010·The American Journal of Drug and Alcohol Abuse·Rajkumar J SevakCraig R Rush
Mar 17, 2006·Drug and Alcohol Dependence·William W StoopsCraig R Rush

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