PMID: 9421826Jan 9, 1998Paper

Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia

Progress in Neuro-psychopharmacology & Biological Psychiatry
P A Broderick

Abstract

1. Although the GABA-A receptor complex has been the main focus of anti-anxiety therapy, the neural interaction in the septohippocampal circuit between GABA-A and the neurotransmitter, 5-HT, compels a study of the monoamine, 5-HT, in anxiety as well. 2. Neurochemistry for anxiety is also intimately involved with the neurotransmitter, NE. Indeed, 5-HT is a component of the dorsal ascending noradrenergic bundle and both neurotransmitters, NE and 5-HT, have been implicated in clinical depression. 3. In vivo microvoltammetric studies were performed using miniature carbon based sensors to detect NE release and concurrent 5-HT release, with 2 separate neural electrochemical signals, within CA1 region of hippocampus, in the chloral hydrate anesthetized rat. 4. Time course studies showed that both the triazolobenzodiazepine (TBZD), alprazolam, and the benzodiazepine (BZD), diazepam, decreased hippocampal NE release. 5. The in vivo and on line neurochemical profile of hippocampal 5-HT release for alprazolam differed from that of diazepam, i.e. alprazolam increased hippocampal 5-HT release, whereas diazepam decreased hippocampal 5-HT release. 6. Time course studies showed that the alpha 2-adrenergic antagonist, yohimbine, an anxiogenic a...Continue Reading

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Citations

Jun 1, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Donn A Simmons, Patricia A Broderick
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Feb 28, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D Bentué-FerrerM Bourin
Feb 25, 2014·The Libyan Journal of Medicine·Najwa Ahmed El Zahaf, Abdalla Salem Elhwuegi
Jan 1, 2007·The Libyan Journal of Medicine·Sm AburawiZm Gorash
Jan 1, 2008·The Libyan Journal of Medicine·Ra Al-TubulyS Errwami
Dec 25, 2007·Anesthesiology·Isao TakamatsuMasayuki Sekiguchi
May 28, 2020·International Clinical Psychopharmacology·Bryant LimSakina J Rizvi

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