Jan 1, 1984

Alprazolam versus lorazepam in the treatment of anxiety: controlled clinical study

Rivista di patologia nervosa e mentale
F BernardiM C Varricchio

Abstract

58 patients suffering from anxiety neurosis were divided into two groups, matched for age, sex, marital status and symptomatology. In a double-blind trial of 4 weeks' duration one group (28 patients) received alprazolam 0.75-3 mg/day and the other (30 patients) received lorazepam 3-12 mg/day. Both groups showed a steady and significant reduction in anxiety levels as measured by Hamilton Anxiety Rating Scale and Clinical Global Impression scores at 0, 1, 2 and 4 weeks. However, there was no significant difference in measured anxiety levels between the two groups at any stage. Fewer side effects were reported in the alprazolam treatment group, with the mental confusion symptom occurring significantly less often.

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Mentioned in this Paper

Lorazepam
CDISC SDTM Marital Status Terminology
Anxiety Disorders
Incisors, Fused Mandibular
Alprazolam
Anxiety States, Neurotic
Cassadan
Double-Blind Method
Randomization
Sedicepan

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