ALS-associated genes display CNS expression in the developing zebrafish

Gene Expression Patterns : GEP
Lauren A LaboissonniereJeffrey M Trimarchi

Abstract

Amyotrophic lateral sclerosis (ALS) is characterized by progressive muscle atrophy resulting from the deterioration of motor neurons in the central nervous system (CNS). Recent genome-wide association studies have revealed several genes linked to ALS, further demonstrating the complexity of the disease. The zebrafish (Danio rerio) is an attractive model organism to study the function of the rapidly expanding number of ALS-associated genes, in part, due to the development of genome editing techniques that have facilitated specific gene targeting. Before investing in the manipulation and phenotypic examination of these genes, however, it is important to ascertain the localization of expression in this organism. We performed an expression analysis of 29 total ALS-linked genes in the developing zebrafish, specifically focusing on those genes that displayed robust and reproducible expression at multiple different timepoints. First, we classified a subset of the most robustly expressed genes into three distinct groups: head-only expression, head and weak trunk expression, and head and robust trunk expression. Then, we defined the characteristic pattern of each gene at 2, 3, and 4 days post fertilization. This analysis will facilitate...Continue Reading

Citations

Jul 3, 2020·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Itzel Sifuentes-RomeroJohanna E Kowalko

❮ Previous
Next ❯

Related Concepts

Related Feeds

ALS: Phenotypes

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized phenotypically by progressive muscle weakness. Clinical phenotypes of ALS can be classified based on the pattern, level, and area of onset (e.g. bulbar, cervical, lumbar). Here is the latest research investigating phenotypes of ALS.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Related Papers

Medizinische Monatsschrift für Pharmazeuten
Annemarie HübersAlbert C Ludolph
European Journal of Human Genetics : EJHG
Nicolas Dupré, Paul Valdmanis
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova
A G GRUSHINA
The Journal of the Association of Physicians of India
© 2022 Meta ULC. All rights reserved