ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics

FEBS Letters
Shinji HadanoJoh-E Ikeda

Abstract

ALS2, the causative gene product for juvenile recessive amyotrophic lateral sclerosis (ALS2), is a guanine-nucleotide exchange factor for the small GTPase Rab5. Here, we report a novel ALS2 homologous gene, ALS2 C-terminal like (ALS2CL), which encodes a 108-kD ALS2CL protein. ALS2CL exhibited a specific but a relatively weak Rab5-GEF activity with accompanying rather strong Rab5-binding properties. In HeLa cells, co-expression of ALS2CL and Rab5A resulted in a unique tubulation phenotype of endosome compartments with significant colocalization of ALS2CL and Rab5A. These results suggest that ALS2CL is a novel factor modulating the Rab5-mediated endosome dynamics in the cells.

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Citations

Oct 24, 2007·Molecular Neurobiology·Jayanth ChandranHuaibin Cai
Jun 28, 2012·Nucleic Acids Research·TaeHyun HwangRui Kuang
Aug 21, 2008·Neuro-degenerative Diseases·Huaibin CaiJayanth Chandran
Aug 19, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Huaibin CaiPhilip C Wong
Jun 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·R S DevonM R Hayden
Oct 9, 2008·Experimental Eye Research·Robert L McKownGordon W Laurie
Jun 28, 2006·Annals of Neurology·Koji YamanakaDon W Cleveland
Jun 28, 2006·Annals of Neurology·Arnaud JacquierGeorg Haase
Dec 7, 2005·Trends in Cell Biology·Darren S CarneyBruce F Horazdovsky
Jan 24, 2007·Biochemical and Biophysical Research Communications·Kyoko Suzuki-UtsunomiyaJoh-E Ikeda
May 19, 2011·The Journal of Biological Chemistry·Hiroaki KajihoToshiaki Katada
Sep 2, 2020·The Journal of Cell Biology·Claudia BaumannRabindranath De La Fuente
Jun 2, 2016·Cell Structure and Function·Morié IshidaMitsunori Fukuda
Dec 8, 2020·Frontiers in Cellular Neuroscience·María José Castellanos-MontielThomas M Durcan
Jul 30, 2021·Epigenomics·Amber Berdenis van BerlekomUNKNOWN Psychiatric Donor Program of the Netherlands Brain Bank (NBB-PSY)

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