PMID: 6159284Jan 1, 1980Paper

Alteration by procaine of spectrin cross-links, deformability, and fluidity related properties of the erythrocyte membrane

Folia haematologica : internationales Magazin für klinische und morphologische Blutforschung
G GeyerH G Geiling

Abstract

The study on procainized human erythrocytes revealed a) temperature dependent changes of cellshapes, b) a significant increase of deformability, c) low amounts of cross-linked membrane proteins, d) a mean cell volume identical with the volume of nonprocainized cells, e) severe reduction of induced anisotropy, f) no loss of negatively charged groups of the glycocalyx, g) decrease of electrophoretic velocity, h) a significant rise of adhesiveness to glass, and i) increase of agglutinability with antiserum and lectin. The findings are discussed in their relationships to alterations of the molecular structure of the red cell membrane.

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