PMID: 9437804Jan 23, 1998Paper

Alteration in cell kinetics in control B6C3F1 mice infected with Helicobacter hepaticus

Toxicologic Pathology
A NyskaJ R Hailey

Abstract

The discovery of Helicobacter hepaticus infection, H. hepaticus hepatitis, and increased incidence of liver tumors in control males from several recent National Toxicology Program B6C3F1 mouse carcinogenicity bioassays raised questions regarding the suitability of these bioassays for hazard identification. The purpose of this study was to determine if changes in cell proliferation and death at terminal sacrifice might be linked to the increased liver tumor incidences among control males. In control males, enhanced rates of hepatocyte proliferation, as assessed by immunostaining for proliferating cell nuclear antigen (PCNA), and apoptosis, as assessed from hematoxylin and eosin- and TUNEL-stained preparations, were seen in 3 bioassays with H. hepaticus hepatitis. One bioassay with H. hepaticus infection without attendant hepatitis and one bioassay without H. hepaticus or hepatitis did not have elevated rates of hepatocyte proliferation or apoptosis. There was no significant effect on PCNA cell proliferation indices or apoptosis in females. The present findings are indicative of a clear association between the presence of H. hepaticus infection with attendant hepatitis, increased cell proliferation and apoptosis, and increased in...Continue Reading

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Citations

Jan 9, 2001·Clinical Microbiology Reviews·J V Solnick, D B Schauer
Oct 30, 2004·Toxicologic Pathology·Samuel R BoutinJames G Fox
Oct 10, 2002·Toxicologic Pathology·Vladimir S TurusovGary A Boorman

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