Alteration in connexin 43 gap junction gene dosage impairs conotruncal heart development

Developmental Biology
G Y HuangC W Lo

Abstract

Connexin 43 (Cx43) knockout mice and transgenic mice (CMV43) overexpressing the Cx43 gap junction gene exhibit heart defects involving the conotruncus and right ventricle. Based on the heart phenotype and Cx43 gene and transgene expression pattern, we previously proposed that the heart defects may reflect a role for gap junctions in the modulation of cardiac neural crest development. To further elucidate the mechanism by which these heart defects may arise, fetal heart structure and function in these transgenic and knockout mice were examined by magnetic resonance microscopy and Doppler echocardiography. Magnetic resonance microscopy of E14.5 fetuses revealed an enlargement of the right ventricular chamber in the heterozygous Cx43 knockout and CMV43 transgenic mice. This was accompanied by thinning of the chamber wall. In the homozygous Cx43 knockout mouse, heart malformation was also restricted to the right ventricle. This was generally characterized by two pouches at the base of the pulmonary outflow tract, but occasionally hearts with a single pouch were found. Magnetic resonance microscopy showed in some of the CMV43 and Cx43 knockout mice an attenuation of the ductus arteriosus, a phenotype which may be indicative of outfl...Continue Reading

References

Aug 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C P Ruangvoravat, C W Lo
Sep 1, 1991·The American Journal of Anatomy·S Miyagawa-TomitaM L Kirby
Mar 1, 1991·Neuron·M V BennettJ C Sáez
Jul 1, 1990·The Journal of Membrane Biology·E C BeyerD A Goodenough
Jan 1, 1989·Anatomy and Embryology·T Franz
Feb 1, 1989·The American Journal of Anatomy·M Vuillemin, T Pexieder
May 1, 1986·International Journal of Cardiology·N J Elzenga, A C Gittenberger-de Groot
Aug 1, 1986·Teratology·E L EffmannT Pexieder
Aug 1, 1995·Circulation Research·M L Kirby, K L Waldo
Mar 24, 1995·Science·A G ReaumeJ Rossant
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·B R SmithE Linney
May 15, 1996·European Journal of Biochemistry·R BruzzoneD L Paul
Oct 1, 1996·Pediatric Research·Y H GuiJ C Huhta
Apr 15, 1997·The Journal of Clinical Investigation·P A GuerreroJ E Saffitz
Mar 20, 1998·Circulation Research·J YaW H Lamers
Mar 1, 1995·Trends in Cardiovascular Medicine·D M NodenA C Gittenberger-de Groot

❮ Previous
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Citations

May 16, 2008·Histochemistry and Cell Biology·Nora Prochnow, Rolf Dermietzel
Aug 21, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alexandra E PetietG Allan Johnson
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kazuki KodoHiroyuki Yamagishi
Aug 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Friso PostmaPatrick O Kanold
Oct 7, 2008·Antioxidants & Redox Signaling·Laurent CronierMarc Mesnil
Aug 6, 2008·Cardiovascular Research·Janet L ManiasDale W Laird
Sep 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Brian BaoJeffrey R Morgan
Jul 11, 2007·TheScientificWorldJournal·Paige SniderSimon J Conway
Nov 7, 2009·Circulation Research·Paige SniderSimon J Conway
May 17, 2000·The Journal of Clinical Investigation·H YanagisawaM Yanagisawa
Oct 8, 2013·PloS One·Kathleen M S E ReyskensM Faadiel Essop
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·J HyerT Mikawa
May 4, 2011·Cellular and Molecular Life Sciences : CMLS·C J J BoogerdP Barnett
Sep 17, 2013·Trends in Genetics : TIG·Francesca C NorrisMark F Lythgoe
Nov 18, 2005·Pediatric Surgery International·Salome Gonzalez-ReyesJuan A Tovar
Oct 27, 2009·Pediatric Surgery International·Montserrat BretJuan A Tovar
Feb 25, 2000·Ultrasound in Medicine & Biology·F S FosterD H Turnbull
Aug 10, 2006·Cell and Tissue Research·Roberto Bruzzone, Rolf Dermietzel
Jun 15, 2012·Differentiation; Research in Biological Diversity·Chelsea L Gregg, Jonathan T Butcher
Dec 17, 2009·Journal of Pediatric Surgery·Kouji NagataTomoaki Taguchi
Mar 29, 2002·The Journal of Investigative Dermatology·Maurice A M van SteenselPeter M Steijlen
Jan 3, 2015·Developmental Biology·Maria Kotini, Roberto Mayor
Jun 23, 2009·Cell Motility and the Cytoskeleton·Stephan OlkRolf Dermietzel
Oct 31, 2006·Echocardiography·Christopher F SpurneyLinda Leatherbury
Sep 29, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jing ZhangYing-Mao Gao
Jul 31, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Chelsea L Gregg, Jonathan T Butcher
May 19, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Cesar A Berrios-OteroDaniel H Turnbull
Dec 27, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Rui Ping Ji, Colin K L Phoon
Jul 25, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David J HeidenreichPhilip R Brauer
Oct 28, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Cesar A Berrios-OteroDaniel H Turnbull
Jun 1, 2012·Medical Hypotheses·Wei-Cheng ChenGuo-Ying Huang
Sep 21, 2000·Current Biology : CB·A PlumK Willecke
Oct 30, 2012·Biochimica Et Biophysica Acta·Shan-Shan Zhang, Robin M Shaw
Jul 26, 2005·Developmental Biology·Diana L WalkerCecilia W Lo
Jan 21, 2004·Developmental Biology·Alexander M SimonHwuDauRw Chen
Feb 28, 2004·Trends in Cardiovascular Medicine·C W Lo, A Wessels

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