Abstract
Although the use of inotropic agents to treat congestive heart failure (CHF) in patients with coronary artery disease has yielded short-term hemodynamic improvement, long-term mortality has shown less improvement. The loss of cardiac muscle as a result of infarction not only decreases the pumping ability of the heart but also leads to some dramatic changes in myocardial energetics. However, little is known about the mechanoenergetics of the heart in patients with left ventricular (LV) dysfunction after myocardial infarction. The present study was designed to compare by means of the Vo2-pressure-volume area relation (PVA, a measure of total mechanical energy) and Emax (LV contractility index), the incremental oxygen cost of contractility measured as nonmechanical energy per unit increment in contractility in patients with various kinds of LV dysfunction. We assessed Emax, Vo2, and PVA using conductance and Webster catheters under control conditions and during different rates of dobutamine infusion (3 and 6 micrograms x kg-1 x min-1) in 30 patients with coronary artery disease. Patients were divided into three groups according to LV ejection fraction (EF): 10 without LV dysfunction (EF>/= 60%), 10 with mild LV dysfunction (40% </...Continue Reading
References
Nov 1, 1992·European Heart Journal·M OdakeM Yokoyama
Nov 1, 1992·European Heart Journal·H TakaokaM Yokoyama
Nov 21, 1991·The New England Journal of Medicine·M PackerM L Kukin
Dec 1, 1990·Journal of Molecular and Cellular Cardiology·M WankerlE Erdmann
Apr 1, 1990·Physiological Reviews·H Suga
May 1, 1990·The Journal of Clinical Investigation·J K GwathmeyJ P Morgan
Jan 11, 1990·The New England Journal of Medicine·A M Katz
Jul 1, 1987·Journal of Applied Physiology·D L GeenenR M Lampman
Jan 1, 1987·Heart and Vessels·D BurkhoffK Sagawa
Aug 1, 1986·The American Journal of Physiology·D BurkhoffK Sagawa
Sep 1, 1985·Journal of the American College of Cardiology·M TakeuchiH Fukuzaki
Mar 1, 1982·The American Journal of Cardiology·D S BaimD C Harrison
Jun 1, 1981·Cardiovascular Research·J BaanJ Koops
Aug 1, 1994·Cardiovascular Research·H TakaokaM Yokoyama
Citations
Nov 13, 2008·Annals of Biomedical Engineering·Kazunori UemuraMasaru Sugimachi
Mar 1, 1997·Journal of the American College of Cardiology·M MoriM Yokoyama
Aug 30, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·C RapezziB Magnani
Feb 15, 2000·Journal of Cardiovascular Pharmacology·H OtaniH Imamura
May 23, 1998·Annual Review of Pharmacology and Toxicology·D K Rohrer, B K Kobilka
Apr 27, 2001·Neurosurgery·J MoccoE S Connolly
Aug 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Luciano C AmadoJoshua M Hare
Sep 12, 2000·Current Cardiology Reports·P P DzejaA Terzic
Sep 10, 2009·European Journal of Pharmacology·Zhen TanWei Dong Gao
Jun 9, 2004·European Journal of Heart Failure·Lazaros A NikolaidisRichard P Shannon
Feb 21, 2004·Clinical Endocrinology·Luigi SaccàAntonio Cittadini
Jul 25, 2000·Journal of Cardiac Failure·G A MacGowan, A P Koretsky
Jan 29, 2005·International Journal of Cardiology·Masaki TanabeTakeshi Nakano
Sep 26, 2007·American Heart Journal·Toshiro ShinkeMitsuhiro Yokoyama
Sep 21, 2013·IET Systems Biology·Takao ShimayoshiTetsuya Matsuda
Oct 27, 2009·Journal of Molecular and Cellular Cardiology·Jeanne JamesJeffrey Robbins
Jan 1, 1997·Heart and Vessels·K NikiS Hosoda
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C KorvaldT Myrmel
Oct 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Susanna Mak, Gary E Newton
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·L A NikolaidisR P Shannon
Apr 6, 2004·The International Journal of Artificial Organs·G FerrariA Mancini