PMID: 6251896Oct 6, 1980Paper

Alteration in enzyme activities of de novo phosphatidylcholine biosynthesis in rat liver by treatment with typical inducers of microsomal drug-metabolizing system

Biochimica Et Biophysica Acta
K IshidateY Nakazawa


1. The activities of choline kinase, ethanolamine kinase, cholinephosphate cytidylytransferase(s) and cholinephosphotransferase were compared in the liver subcellular fractions after the treatment of rats for two successive days with phenobarbital, 3-methylcholanthrene and polychlorinated biphenyls. 2. The administration of phenobarbital resulted in a significant decrease in choline kinase activity while not affecting ethanolamine kinase activity. Both 3-methylcholanthrene and polychlorinated biphenyls caused considerable enhancement of choline kinase activity concomitantly with ethanolamine kinase activity. 3. The activity of cytosolic cytidylytransferase was not affected by any of the inducers while the microsomal activity was significantly depressed by the administration of either phenobarbital or polychlorinated biphenyls. 4. The activity of microsomal cholinephosphotransferase decreased significantly after the treatment with both 3-methylcholanthrene and polychlorinated biphenyls and increased slightly after phenobarbital administration. 5. The observed opposite effects of phenobarbital and 3-methylcholanthrene on the enzymes in de novo phosphatidylcholine synthesis indicate that there exist a possible relation between ind...Continue Reading


May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·A P AlvaresA Kappas


Jan 1, 1981·Progress in Biophysics and Molecular Biology·P J Quinn
Feb 1, 1984·Toxicology Letters·Y SinghU K Misra
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M E HarrisD P Selivonchick
Nov 25, 1997·Biochimica Et Biophysica Acta·K Ishidate
May 1, 1985·Archives of Biochemistry and Biophysics·K WakuS Yamashina
May 5, 1999·Chemico-biological Interactions·N KudoY Kawashima
Sep 30, 1980·Biochemical and Biophysical Research Communications·K IshidateY Nakazawa
Mar 16, 1983·Biochemical and Biophysical Research Communications·K IshidateY Nakazawa

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