PMID: 7523274Nov 1, 1994Paper

Alteration in growth regulation of hepatocytes in primary culture obtained from cirrhotic rat: poor response to transforming growth factor-beta 1 and interferons

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
S KisoY Matsuzawa

Abstract

Cell growth appears to be controlled by positive and negative cell growth regulation. Little is known about the growth regulation of hepatocytes in the cirrhotic liver. Clarifying the responses of hepatocytes obtained from cirrhotic liver to various growth factors and growth inhibitory factors might aid understanding of alterations in growth regulation of the hepatocytes in the cirrhotic liver. We investigated the effects of hepatocyte growth factor, epidermal growth factor, heparin-binding epidermal growth factor-like growth factor, transforming growth factor-beta 1, interferon-alpha and interferon-gamma on the DNA synthesis of hepatocytes from cirrhotic and normal rats in primary culture. Cirrhosis was induced in male Sprague-Dawley rats by means of oral administration of 0.05% thioacetamide in drinking water for 4 mo. Hepatocytes were isolated by means of an in situ perfusion method, and DNA synthesis was assessed from the amount of DNA-incorporated [3H]thymidine. Stimulation of the DNA synthesis of hepatocytes by hepatocyte growth factor, epidermal growth factor and heparin-binding epidermal growth factor-like growth factor was not different between normal and cirrhotic rat liver. Transforming growth factor-beta 1 inhibited...Continue Reading

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Citations

Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K FukudaY Matsuzawa
Apr 21, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rajendra PersadAsif Rashid
Jun 11, 2005·Journal of Gastroenterology and Hepatology·Takako KawasakiYuji Matsuzawa
May 29, 2008·Journal of Gastroenterology and Hepatology·Olav A GressnerAxel M Gressner
Aug 1, 2007·Comparative Hepatology·Olav A GressnerAxel M Gressner
Aug 14, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takayo TakemuraTetsuo Takehara
Aug 11, 2000·Seminars in Cancer Biology·S Kanzler, P R Galle
Mar 13, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Olav A Gressner, Chunfang Gao
Nov 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S KisoY Matsuzawa

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