Alteration in IL-1 and arginase activity of tumor-associated macrophages: a role in the promotion of tumor growth

Cancer Letters
P Parajuli, S M Singh

Abstract

The present investigations were undertaken to study whether the macrophages associated with Dalton's lymphoma (DLAM), a spontaneous T-cell lymphoma, are modulated for the secretion of tumor growth-promoting factors in ascites. The DL ascitic fluid (DLAF) and the culture supernatants of DLAM harvested from mid and late tumor-bearing stages, but not early tumor-bearing stage, enhanced the proliferation of DL cells in vitro. These observations indicate that DLAF contains certain DL growth-promoting substances and at least some of them are secreted by DLAM. The DLAM obtained from mid and late tumor-bearing stages showed enhanced IL-1 production and arginase activity, with a concomitant decline in the RNI production, which could be implicated in the DLAM-mediated promotion of tumor growth.

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Citations

Dec 3, 2009·International Immunology·Praveen DeepakArbind Acharya
Jun 24, 2008·Immunopharmacology and Immunotoxicology·Alok Kumar SinghSukh Mahendra Singh
Jun 23, 2015·Immunology Letters·Maria Teresa P de AquinoAnil Shanker
Apr 29, 2005·Comparative Immunology, Microbiology and Infectious Diseases·Mahendra Pal SinghSukh Mahendra Singh
Apr 29, 2020·Blood Advances·Andrea SitlingerDavid B Bartlett
Feb 12, 1998·The American Journal of Physiology·C I ChangL Kuo
Mar 6, 2004·International Journal of Immunopathology and Pharmacology·P ShrivastavaN Singh

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