Alteration in Kupffer cell function after mild hemorrhagic shock

Shock
J P HuntC C Baker

Abstract

Functional changes in Kupffer cells occur after profound hemorrhagic shock. This study was performed to demonstrate if Kupffer cell changes also occur after mild hemorrhagic shock. Sprague-Dawley rats were bled to a systolic blood pressure of 60 to 70 mmHg and resuscitated with Lactated Ringers solution (twice the shed blood volume) after 30 min. Resuscitation produced immediate recovery of blood pressure and allowed long-term recovery of the animals. Sham animals received anesthesia and monitoring only. Thirty minutes after resuscitation, Kupffer cells were isolated by centrifugal elutriation and cultured for 48 h. In Kupffer cells isolated from shocked animals, phorbol ester-stimulated superoxide production increased 7-fold and lipopolysaccharide- (LPS) stimulated prostaglandin E2 (PGE2) production increased 4-fold. Tumor necrosis factor-alpha (TNFalpha) production, on the other hand, was decreased by 50%. A non-significant trend toward increased phagocytosis was also observed, whereas LPS-stimulated nitric oxide production was unchanged. In conclusion, mild hemorrhagic shock produced increases in superoxide and PGE2 production, and decreases in TNFalpha production by Kupffer cells, changes that may be appropriate to defend a...Continue Reading

Citations

Jul 11, 2002·Free Radical Biology & Medicine·Hartmut Jaeschke, Anwar Farhood
Apr 19, 2012·Preparative Biochemistry & Biotechnology·Jirka GrosseDaniela Grimm
Jun 5, 2004·The Journal of Trauma·José Gustavo ParreiraMaurício Rocha e Silva
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Jul 14, 2012·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Christoph CzernyJohn J Lemasters
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Dec 3, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kazuaki TaguchiMasaki Otagiri

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