PMID: 9444502Jan 28, 1998Paper

Alteration in leukocyte adhesion molecule expression following minor, moderate and major trauma

European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine
R A Cocks, T Y Chan

Abstract

An understanding of the mechanisms of post-injury leukocyte trafficking is essential to the development of future therapeutic interventions aimed at preventing infection and multiple organ failure in trauma patients, yet very little is known about the cellular and molecular events resulting in mobilization of members of the leukocyte family following trauma. We have studied the post-injury expression of the lymphocyte, monocyte and neutrophil adhesion molecules CD11a (LFA-1), CD11b, CD11c, CD29 (beta-1 integrin) and CD62L (L-selectin) in a group of 36 trauma patients, 13 of whom had suffered major trauma (ISS > or = 16), 15 moderate trauma (ISS = 9-15) and eight minor trauma (ISS < 9). Three ml blood samples were taken within 2.5 h of injury (mean sample time = 1.2 h, median = 1 h) into EDTA anticoagulant. Fifty-three normal control subjects were also studied for comparison. Leukocytes were stained using fluorescent-labelled monoclonal antibodies specific for each adhesion molecule, and the mean receptor density per cell measured using flow cytometry. Monocytes, neutrophils and lymphocytes in the trauma patients showed significantly increased mean-receptor density of L-selectin (p < 0.0001, 0.0001 and 0.004 respectively). Neutr...Continue Reading

Citations

Feb 14, 2002·Resuscitation·Timothy H Rainer
Aug 31, 2000·Critical Care Medicine·T H RainerR A Cocks
Aug 19, 2007·The Journal of Trauma·Michael FrinkMartijn van Griensven
Jul 1, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Patrick PaulusKai Zacharowski

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