Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Feng ZhangWeidong Le

Abstract

The present work aims to evaluate the significance of sleep disturbance and electroencephalogram (EEG) alteration in the early stage of Alzheimer's disease (AD). Sleep disturbance is common in patients with AD. It is not known if it can occur at the early stage of AD and if EEG recording may help identify the early sign of the disease. Sleep disturbance in AD has generally been considered as late consequence of the neurodegenerative process. A growing body of evidence has suggested that the sleep disturbance may occur at the early stage of AD. Based on the previous epidemiologic studies and our recent findings, we propose that sleep disturbance may play an important role in the development of AD. Sleep EEG changes may serve as a valuable early sign for AD in the prepathological stage. Our data suggested that AβPPswe/PS1ΔE9 transgenic AD mice at preplaque stage (3 and 4 months of age) exhibited different profile of sleep architecture and sleep EEG, which preceded the cognitive deficit and AD neuropathology. Future experiments should focus on sleep EEG changes in patients with mild cognitive impairment and early stage of AD. Follow-up studies in high-risk population of the elderly are equally important. In addition, the exact mol...Continue Reading

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Citations

May 3, 2020·International Journal of Molecular Sciences·Ramon Cacabelos
May 31, 2019·Current Neurology and Neuroscience Reports·Gustavo C RománAparajitha K Verma
Dec 7, 2019·Neuroscience Bulletin·Chao HeChenggang Jiang
Sep 5, 2020·NPJ Digital Medicine·Niranjan SridharLance Myers
Feb 14, 2020·International Journal of Molecular Sciences·Maria-Angeles LloretAna Lloret
Dec 4, 2020·Acta Pharmacologica Sinica·Feng ZhangWei-Dong Le
Dec 10, 2020·International Journal of Molecular Sciences·Matthias KreuzerPaul S García
Feb 19, 2021·NPJ Digital Medicine·Niranjan SridharLance Myers
Mar 2, 2021·Neural Regeneration Research·Huang KuangShu-Long Yang
Sep 11, 2021·Nature Communications·Julie GonneaudUNKNOWN Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group
Sep 11, 2021·Chinese Medical Journal·Willa D BrenowitzYue Leng

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