Alteration in the expression of inflammatory parameters as a result of oxidative stress produced by moderate zinc deficiency in rat lung

Experimental Lung Research
Veronica S BiaggioMaría S Gimenez

Abstract

Suboptimal intake of dietary zinc (Zn) is one of the most common nutritional problems worldwide. Previously, the authors have shown that zinc deficiency (ZD) produces oxidative and nitrosative stress in lung of male rats. The goal of this study is to test the effect of moderate ZD on insulin-like growth factor (IGF)-1, IGF-binding protein (IGFBP)-5, NADH oxidase (NOX)-2, tumor necrosis factor alpha (TNFalpha), as well as the effect of restoring zinc during the refeeding period. Adult male rats were divided into 3 groups: Zn-adequate control group, Zn-deficient group, and Zn-refeeding group. eNOS, metallothionein (MT) II, and NOX-2 was increased in ZD group. The authors observed an increased gene transcription of superoxide dismutase (SOD)-2 and gluthathione peroxidase (GPx)-1 in ZD group, as well as in ZD-refeeding group, but catalase (CAT) transcription did not change in the treated groups. Proinflammatory factors, such as TNFalpha and vascular cell adhesion molecular (VCAM)-1 increased in ZD, whereas it decreased in ZD refeeding. However, peroxisome proliferator-activated receptor gamma (PPARgamma) and IGF-1 gene transcription decreased in ZD, whereas IGFBP-5 decreased in the ZD group. These parameters are associated to alter...Continue Reading

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Feb 1, 1975·Analytical Biochemistry·C Wang, R L Smith
Nov 1, 1990·The Journal of Nutrition·J C King
Dec 1, 1994·The Journal of Clinical Investigation·P W ShaulR A Star
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·J S Lazo, B R Pitt
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·W Maret
Jan 1, 1993·Free Radical Research Communications·R E Huie, S Padmaja
Mar 17, 1997·FEBS Letters·D BerendjiK D Kröncke
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·C JacobB L Vallee
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·D MorrisonW MacNee
Nov 11, 1999·Neurochemical Research·J Liu, A Mori
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·Z H ZhouL W Zhu
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·A Q Truong-TranP D Zalewski
Feb 24, 2001·American Journal of Physiology. Renal Physiology·R Govers, T J Rabelink
Apr 11, 2002·Lipids·N N GomezM S Gimenez
Oct 3, 2002·Biochemical and Biophysical Research Communications·Joanne E CarterPeter D Zalewski
Oct 2, 2003·The Journal of Nutrition·Purushothaman MeeraraniBernhard Hennig
Jan 9, 2004·Experimental Lung Research·Nidia N GomezMaría S Gimenez
Feb 6, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R L TorresA A Belló
May 22, 2004·Journal of Pharmacological Sciences·Hyoung Chul Choi, Kwang Youn Lee
Jun 24, 2004·The Journal of Biological Chemistry·Christian SchwarzerHorst Fischer
Jan 14, 2005·Molecular and Cellular Biochemistry·Marian ValkoJoshua Telser
Mar 17, 2006·Current Opinion in Pharmacology·Peter D Zalewski

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Citations

Oct 25, 2011·The British Journal of Nutrition·Verónica S BiaggioNidia N Gomez
Feb 20, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Verónica S BiaggioMaría S Gimenez
Nov 26, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Li JingShuangqing Peng
Apr 23, 2020·International Journal of Molecular Medicine·Anatoly V SkalnyAlexey A Tinkov
Oct 24, 2020·Nutrients·Francesco PecoraSusanna Esposito
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wagner Gouvea Dos Santos
Sep 23, 2021·Journal of the American College of Nutrition·Alessio AlesciNicola Cicero

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