Alteration of β-Adrenoceptor Signaling in Left Ventricle of Acute Phase Takotsubo Syndrome: a Human Study

Scientific Reports
Tomoya NakanoYoshihiko Saito

Abstract

Accumulating evidence indicates alteration of the β-adrenoceptor (AR), such as desensitization and subtype switching of its coupling G protein, plays a role in the protection against catecholamine toxicity in heart failure. However, in human takotsubo syndrome (TTS), which is associated with a surge of circulating catecholamine in the acute phase, there is no histologic evidence of β-AR alteration. The purpose of this study was to investigate the involvement of alteration of β-AR signaling in the mechanism of TTS development. Left ventricular (LV) biopsied samples from 26 patients with TTS, 19 with normal LV function, and 26 with dilated cardiomyopathy (DCM) were studied. G protein-coupled receptor kinase 2 (GRK2) and β-arrestin2, which initiate the alteration of β-AR signaling, were more abundantly expressed in the myocardium in acute-phase TTS than in those of DCM and normal control as indicated by immunohistochemistry. The percentage of cardiomyocytes that showed positive membrane staining for GRK2 and β-arrestin2 was also significantly higher in acute-phase TTS. Sequential biopsies in the recovery-phase for two patients with TTS revealed that membrane expression of GRK2 and β-arrestin2 faded over time. This study provided t...Continue Reading

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Citations

Jun 21, 2020·Echocardiography·Nicola TarantinoNatale Daniele Brunetti
Dec 17, 2019·Journal of Cardiothoracic and Vascular Anesthesia·Alessandro BellettiSilvia Ajello
Jan 30, 2021·Arkhiv patologii·L V KakturskiyA E Komlev
Nov 6, 2020·Journal of cardiology·Hiroyuki Okura
Feb 18, 2021·Journal of cardiology·Hiroyuki Okura
Mar 18, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Kenan YaltaTulin Yalta
Jun 23, 2021·Cardiovascular Research·Liam S CouchSian E Harding

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Methods Mentioned

BETA
biopsy

Software Mentioned

JMP

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