PMID: 9419269Feb 28, 1998Paper

Alteration of [14C]-testosterone metabolism after chronic exposure of Daphnia magna to tributyltin

Archives of Environmental Contamination and Toxicology
E OberdörsterG A LeBlanc

Abstract

Tributyltin (TBT) is a marine biocide that has been shown to alter the activity of cytochrome P450 monooxygenases and elicit toxicity indicative of androgenization in some species. The present study was conducted to determine whether TBT altered P450-, reductase-, and transferase-mediated testosterone metabolic processes in Daphnia magna at sublethal exposure concentrations. Two generations of daphnids were continuously exposed for 21 days to nominal TBT concentrations ranging from 0.31 to 2.5 microg/L TBT. The highest TBT concentration (2.5 microg/L) was lethal to 60% of the exposed organisms. Lower TBT concentrations elicited no adverse effects on molting or reproduction of the daphnids. No differences were observed in the response of the first- and second-generation daphnids to the toxicity of TBT. The ability of daphnids to metabolize [14C]-testosterone in vivo was assessed following exposure of each generation to TBT. Production of hydroxylated, reduced/dehydrogenated, and glucose-conjugated metabolites of testosterone were all elevated following exposure of both generations to 1.25 microg/L TBT. These findings indicate that, under these conditions, TBT elicits no discernible effects on molting and reproduction of daphnids...Continue Reading

Citations

Oct 3, 2003·Biochemical and Biophysical Research Communications·Kim RewitzOle Andersen
Feb 27, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Donna R Kashian
Mar 26, 2004·Marine Pollution Bulletin·Naoyoshi KubotaAkira Kitamura
Jun 1, 2005·General and Comparative Endocrinology·G JanerC Porte
Aug 28, 2001·Steroids·D D HeidrichD Klingmuller
Sep 17, 2002·Steroids·Dagmar D DoeringDietrich Klingmüller
Jun 19, 2004·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Mari Golub, John Doherty
Jun 27, 2003·Environmental Health Perspectives·Wade V WelshonsFrederick S vom Saal
Aug 3, 2012·Journal of Toxicology and Environmental Health. Part a·Priscila Lang PodratzJones Bernardes Graceli
Jan 24, 2016·Chemosphere·Pearl U OfoegbuJoão L T Pestana
Sep 8, 2004·Journal of Morphology·Katrin KronenbergerVolker Storch
May 13, 2008·Marine Pollution Bulletin·Haruo MimuraAkira Kitamura
Feb 3, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Enmin Zou, Ryan Bonvillain
Jun 9, 2015·Reproductive Toxicology·Priscila L PodratzJones B Graceli
May 10, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Singaram GopalakrishnanKe-Jian Wang
Sep 30, 1999·Toxicology and Applied Pharmacology·E OberdörsterJ A McLachlan
Oct 28, 2015·Environmental Toxicology and Chemistry·Bruno CamposCarlos Barata
Jun 25, 2005·Marine Biotechnology·Werner SchrothBernd Schierwater
Mar 15, 2018·Frontiers in Endocrinology·Éverton L VogtAnapaula S Vinagre

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.