Alteration of ATP-sensitive K+ channels in rabbit aortic smooth muscle during left ventricular hypertrophy

American Journal of Physiology. Cell Physiology
Won Sun ParkJin Han

Abstract

We investigated the impairment of ATP-sensitive K(+) (K(ATP)) channels in aortic smooth muscle cells (ASMCs) from isoproterenol-induced hypertrophied rabbits. The amplitude of K(ATP) channels induced by the K(ATP) channel opener pinacidil (10 μM) was greater in ASMCs from control than from hypertrophied animals. In phenylephrine-preconstricted aortic rings, pinacidil induced relaxation in a dose-dependent manner. The dose-dependent curve was shifted to the right in the hypertrophied (EC(50): 17.80 ± 3.28 μM) compared with the control model (EC(50): 6.69 ± 2.40 μM). Although the level of Kir6.2 subtype expression did not differ between ASMCs from the control and hypertrophied models, those of the Kir6.1 and SUR2B subtypes were decreased in the hypertrophied model. Application of the calcitonin-gene related peptide (100 nM) and adenylyl cyclase activator forskolin (10 μM), which activates protein kinase A (PKA) and consequently K(ATP) channels, induced a K(ATP) current in both control and hypertrophied animals; however, the K(ATP) current amplitude did not differ between the two groups. Furthermore, PKA expression was not altered between the control and hypertrophied animals. These results suggests that the decreased K(ATP) curre...Continue Reading

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Citations

May 6, 2014·Biochemistry. Biokhimii︠a︡·A A ParkhitkoE P Henske
Sep 2, 2016·Biological & Pharmaceutical Bulletin·Takayuki MatsumotoTsuneo Kobayashi
Mar 16, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Charles E Norton, Steven S Segal
Jun 2, 2018·Pflügers Archiv : European journal of physiology·Hongliang LiWon Sun Park
Oct 12, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Charles E NortonSteven S Segal

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