Alteration of Bile Acid Metabolism by a High-Fat Diet Is Associated with Plasma Transaminase Activities and Glucose Intolerance in Rats

Journal of Nutritional Science and Vitaminology
Reika YoshitsuguSatoshi Ishizuka

Abstract

Ingestion of a high-fat (HF) diet is known to enhance bile acid (BA) secretion, but precise information about the BA molecular species is lacking, especially information on the conjugated BAs in enterohepatic circulation. As cholesterol is the precursor of BAs, we analyzed alterations of the entire BA metabolic pathway in response to a HF diet without the addition of cholesterol and BA in the diet. Additionally, we evaluated the relationships between BA metabolism and some disorders, such as plasma transaminase activities and glucose intolerance induced by the HF diet. Acclimated WKAH/HkmSlc male rats (3 wk old) were divided into two groups fed a control or the HF diet for 22 wk. Fasting blood glucose was measured during the experimental period, and an intraperitoneal glucose tolerance test was performed at week 21. As a result, ingestion of the HF diet selectively increased the concentration of taurocholic acid in the bile and small intestinal contents as well as deoxycholic acid in the large intestinal contents and feces. These results indicated a selective increase of 12α-hydroxylated BA concentrations in response to the HF diet. Moreover, fecal 12α-hydroxylated BA concentration was positively correlated with cumulative ener...Continue Reading

References

Jan 1, 1979·Acta Radiologica: Oncology, Radiation, Physics, Biology·I BosaeusC Nyström
Oct 1, 1994·Metabolism: Clinical and Experimental·M JeevanandamS R Petersen
Feb 12, 1998·The American Journal of Physiology·A L CraddockP A Dawson
Jul 10, 2003·Pflügers Archiv : European journal of physiology·Bruno Hagenbuch, Paul Dawson
Jan 1, 1990·Archives of Gerontology and Geriatrics·K UchidaN Takeuchi
Nov 22, 2005·Journal of Lipid Research·Jason M RidlonPhillip B Hylemon
Apr 12, 2007·Obesity·Roland BuettnerL Cornelius Bollheimer
Sep 6, 2008·Journal of Lipid Research·Masahito HagioSatoshi Ishizuka
Sep 18, 2008·American Journal of Physiology. Endocrinology and Metabolism·J CachoM P Ramos
Jan 8, 2009·Physiological Reviews·Philippe LefebvreBart Staels
Aug 21, 2009·Journal of Thrombosis and Haemostasis : JTH·S G ChuJ S Berger
Oct 28, 2010·Nutrition Research Reviews·Niloofar Hariri, Louise Thibault
Dec 9, 2010·The Journal of Physiological Sciences : JPS·Allain Amador BuenoCláudia Maria Oller do Nascimento
Jul 13, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Peizhen SongCurtis D Klaassen
Nov 16, 2011·Bulletin of the World Health Organization·Kumanan Rasanathan, Rüdiger Krech
Sep 27, 2013·International Journal of Health Services : Planning, Administration, Evaluation·Alison Rosamund Katz
Apr 19, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Nakayuki NaritakaToshiaki Shimizu
Jun 6, 2015·Circulation. Cardiovascular Genetics·Stephanie RossGuillaume Paré
Jun 21, 2016·Journal of Pediatric Gastroenterology and Nutrition·Richard D SembaMark J Manary
Apr 6, 2017·American Journal of Physiology. Endocrinology and Metabolism·Enrico BertaggiaRebecca A Haeusler

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Citations

Jan 14, 2021·The Journal of Nutrition·Shota HoriSatoshi Ishizuka
Sep 9, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Ja-Young LeeSatoshi Ishizuka
Jun 14, 2020·The Journal of Nutritional Biochemistry·Shota HoriSatoshi Ishizuka
Oct 16, 2021·Nature Biotechnology·Martin A HoffmannSebastian Böcker

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