PMID: 2499275May 1, 1989Paper

Alteration of biogenic amines in mouse brain regions by alkylating agents. I. Effects of aflatoxin B1 on brain monoamines concentrations and activities of metabolizing enzymes

Archives of Environmental Contamination and Toxicology
S JayasekaraR P Sharma

Abstract

Young adult male CD-1 mice were treated orally twice weekly for three weeks with 0, 0.05, 0.15 or 0.65 mg/kg of aflatoxin B1 (AFB1) in corn oil. Two days after the last dose, the mice were killed by decapitation and the concentrations of the brain catecholamines, norepinephrine (NE), and dopamine (DA), and their metabolites, 3-methoxy-4-hydroxymandelic (VMA), homovanillic acid (HVA) and dihydroxyphenyl acetic acid (DOPAC) and the indoleamine serotonin (5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA) were determined by high pressure liquid chromatography in six discrete brain regions. Major effects of AFB1 were found in the concentrations of NE in most brain areas. Endogenous concentrations of DA were increased in the striatum and hypothalamus. The VMA level in the hypothalamus and striatum were decreased by the treatment. The activity of tyrosine hydroxylase, tryptophan hydroxylase, amino acid decarboxylase and monoamine oxidase (the enzymes important in synthetic and degradation pathways of biogenic amines) were investigated. Alterations in biogenic amine concentrations were often consistent with the changes observed in metabolizing enzymes. There was an increase noted in tryptophan hydroxylase activity. Activiti...Continue Reading

References

Dec 1, 1978·Food and Cosmetics Toxicology·J H LalorG C Llewellyn
Aug 1, 1975·Chemico-biological Interactions·R C Garner, C M Wright
Sep 30, 1985·Toxicology and Applied Pharmacology·R A Coulombe, R P Sharma
Feb 1, 1987·Toxicology·R V ReddyR P Sharma
Jan 1, 1971·Journal of Neurochemistry·B Jarrott
Jan 1, 1969·Journal of the American Oil Chemists' Society·T C Campbell, J H Snider
Jan 1, 1983·Toxicology·F I Ikegwuonu
Jun 1, 1984·Toxicology Letters·N Ahmed, U S Singh
Jan 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L B Weekley, G C Llewellyn
Mar 1, 1983·Journal of Neurochemistry·S J BeeversC I Pogson
Aug 1, 1980·Toxicology and Applied Pharmacology·Z A Wong, D P Hsieh
Jan 1, 1981·Chemico-biological Interactions·M A Pereira, L W Chang
Sep 1, 1964·Analytical Biochemistry·T NAGATSUS UDENFRIEND

❮ Previous
Next ❯

Citations

Jul 5, 2015·Neurotoxicology·Fatima TrebakRabia Magoul

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

© 2022 Meta ULC. All rights reserved