Abstract
Cell-mediated immune reactivity, measured by lymphocyte responsiveness to phytohemagglutinin, was higher in both young or aged mice fed a 4% casein diet compared with age-matched controls. Treatment in vivo with bovine thymosin fraction V decreased the responsiveness to phytohemagglutinin of lymphocytes from mice fed either the control or moderately protein-deficient diets when compared with mice treated in vivo with saline. Resistance against Listeria monocytogenes, known to be a cell-mediated immune function, was impaired in young and aged mice which were fed the low-protein diet. Treatment with thymosin was able to significantly improve the cell-mediated immune resistance to L. monocytogenes of moderately protein-malnourished mice. Thymosin treatment impaired the resistance to L. monocytogenes of young or aged mice fed the control diet. The splenic natural killer cell cytotoxicity of protein-malnourished mice was impaired compared with that of mice fed the control diet. Treatment with thymosin did not restore the natural killer cell cytotoxic activity in protein-malnourished mice, but did enhance that activity in control mice.
References
Aug 1, 1978·The Journal of Infectious Diseases·G T KeuschK Braden
May 1, 1976·The Journal of Experimental Medicine·L ShouR A Good
Jun 1, 1979·Infection and Immunity·M Khorshidi, N Mohagheghpour
Jan 1, 1978·Advances in Cancer Research·R B Herberman, H T Holden
Dec 1, 1979·CRC Critical Reviews in Food Science and Nutrition·R R Watson, D N McMurray
Jan 1, 1979·Annals of the New York Academy of Sciences·T L LowA L Goldstein
Feb 1, 1977·Infection and Immunity·P EmmerlingH Hof
Feb 1, 1976·Cellular Immunology·I Malavé, M Layrisse
Dec 1, 1976·The Journal of Nutrition·R R WatsonR L Baehner
Jan 9, 1975·The New England Journal of Medicine·D W WaraA J Ammann
Jan 1, 1976·Clinical Immunology and Immunopathology·K Schopfer, S D Douglas
Nov 1, 1973·The American Journal of Clinical Nutrition·M GraceyD E Stone
Jun 1, 1974·The American Journal of Clinical Nutrition·W C CooperT Mariani
May 1, 1972·The Journal of Experimental Medicine·F C Lane, E R Unanue
May 1, 1980·Clinical Immunology and Immunopathology·I Bongiorni-Malavé, M Pocino
Mar 1, 1980·Mechanisms of Ageing and Development·R R Watson, K Haffer
Jan 1, 1980·Infection and Immunity·J C Petit
Apr 1, 1981·Infection and Immunity·T M Petro, J K Bhattacharjee
Jul 1, 1980·Journal of Gerontology·R H Weindruch, S C Suffin
Jul 1, 1958·The Journal of Experimental Medicine·R J DUBOS, R W SCHAEDLER
May 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·T A KOERNERE R LONG