PMID: 6171914Nov 1, 1981Paper

Alteration of cerebral neurotransmitter receptor function by exposure of rats to manganese

Toxicology Letters
P K SethS C Bondy

Abstract

Adult male rats were treated on 15 successive days with i.p. injection of manganese chloride at 10 or 15 mg/kg body weight. 24 h after the last dose, the binding of the dopaminergic antagonist [3H]spiroperidol to striatal membranes was elevated significantly. At the lower dose, no other high-affinity binding site measured was altered. However, at the 15 mg/kg body weight dose, cerebellar GABA, frontal cortical serotonin, and striatal muscarinic binding were all depressed. Neither dose level altered striatal levels of enkephalin, substance P, dopamine, serotonin, or dihydroxyphenylacetic acid (DOPAC). Receptor binding measurements may be a sensitive means of detecting disturbances of specific neural circuits.

References

Dec 1, 1979·Journal of Neurochemistry·S V ChandraD K Saxena
Sep 1, 1978·Journal of Toxicology and Environmental Health·M KimuraY Itokawa
Nov 1, 1969·Archives of Environmental Health·S Tanaka, J Lieben
Mar 30, 1981·Toxicology and Applied Pharmacology·A K AgrawalS C Bondy
Jan 1, 1977·Neuroscience Letters·B Roussel, B Renaud

❮ Previous
Next ❯

Citations

Oct 1, 1982·Bulletin of Environmental Contamination and Toxicology·A K AgrawalP K Seth
Jun 1, 1994·Journal of Toxicology and Environmental Health·V VillalobosJ O Dávila
Jun 13, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Neal C BurtonTomás R Guilarte
Apr 2, 2009·Environmental Health Perspectives·Neal C Burton, Tomás R Guilarte
Feb 12, 2013·Free Radical Biology & Medicine·Ebany J Martinez-FinleyThomas E Gunter
Mar 6, 2013·European Journal of Pharmacology·Sanders A McDougallCynthia A Crawford
Mar 27, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sherleen Xue-Fu AdamsonWei Zheng
Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·S K BhattacharyaP K Seth
Jul 1, 1997·Clinical Reviews in Allergy & Immunology·A Montanaro
Jan 1, 1985·Critical Reviews in Toxicology·S C Bondy
Dec 1, 1983·Biochemical Pharmacology·A K AgrawalP K Seth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
G W LipeS F Ali
Toxicological Sciences : an Official Journal of the Society of Toxicology
Stephen H ReaneyDonald R Smith
© 2021 Meta ULC. All rights reserved