Alteration of clonal profile. II. Studies on the capacity of BALB/c splenic B cells to perpetuate responsiveness to phosphorylcholine and T 15 idiotypic dominance

European Journal of Immunology
J QuintánsB Regueiro

Abstract

(CBA/N x BALB/c)F1 hybrid male mice are unable to mount anti-phosphorylcholine (PC) plaque-forming cell (PFC) responses because they carry the CBA/N X-linked immune defect of B lymphocyte differentiation. Transplantation of splenic B cells from BALB/c mice restores responsiveness to thymus-dependent and thymus-independent PC antigens up to 8 months after cell transfer. Cytotoxicity studies demonstrate the donor origin of PFC generated in reconstituted (CBA/N x BALB/c)F1 mice. Although responsiveness to PC is restored permanently, a shift in idiotype expression that leads to the loss of T 15 idiotypic dominance 3 months after cell transfer can be detected. This shift originates from Ig- cells because Ig+ splenic cells purified in a fluorescence-activated cell sorter maintain T 15 dominance. Therefore, the Ig+ cells have a remarkable capacity to maintain responsiveness to antigens and can perpetuate idiotypic dominance if the stem cell pool is removed.

References

Jun 30, 1975·Annals of the New York Academy of Sciences·M R Loken, L A Herzenber
Oct 1, 1975·The Journal of Experimental Medicine·E Heber-Katz, D B Wilson
Jul 1, 1976·European Journal of Immunology·A Augustin, H Cosenza
Jan 1, 1978·The Journal of Experimental Medicine·M P CancroN R Klinman
Dec 1, 1977·European Journal of Immunology·R S AccollaN R Klinman
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D R KaplanH Köhler
Oct 1, 1977·European Journal of Immunology·J Quintáns
Jan 1, 1976·Nature·N H SigalN R Klinman
Apr 1, 1974·The Journal of Experimental Medicine·R LiebermanS Rudikoff
Jan 18, 1966·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·L W Coppleson, D Michie
Sep 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Cosenza, H Köhler
Feb 29, 1972·Biochemistry·B Chesebro, H Metzger
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Jan 1, 1951·The Journal of Experimental Medicine·H C ANDERSON, M McCARTY
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·D E Mosier, L W Coppleson
Apr 26, 1963·Science·N K Jerne, A A Nordin

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Citations

Aug 1, 1989·Immunological Reviews·J Quintáns
Jan 1, 1982·Immunological Reviews·P W KincadeG Lee
Apr 19, 2020·Immunological Reviews·Zhaolin Hua, Baidong Hou
Jan 30, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J M ZimmererG L Bumgardner
Apr 23, 2002·Scandinavian Journal of Immunology·M HolmdahlR Holmdahl

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