Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix

Cancer Letters
T H CheungY F Wong

Abstract

Amplification and overexpression of cyclin D1 and CDK4 genes in cervical carcinoma were studied by semi-quantitative differential polymerase chain reaction assay and an immunostaining technique, respectively. Amplifications of cyclin D1 and CDK4 genes were found in 24% (27/113) and 26% (29/112) of tumors, respectively. Overexpression of cyclin D1 and CDK4 was demonstrated in 32% (21/66) and 73% (45/62) of tumors, respectively. No tumor showed CDK4 gene mutation on single strand conformational polymorphism. Sixteen percent (8/49) of the tumor specimens showed neither amplification nor overexpression. Disease stage, tumor grade and overexpression of cyclin D1 were found to be independent poor prognostic factors in cervical carcinoma.

References

Aug 1, 1989·British Journal of Obstetrics and Gynaecology·J H Shepherd
Nov 1, 1995·Glia·V P Collins
Mar 1, 1997·Molecular Carcinogenesis·T KanumaN Wake
Jan 8, 1998·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·N H ChoJ W Kim

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Citations

Apr 28, 2005·Journal of Cancer Research and Clinical Oncology·Ratnesh Kumar SinghChinmay Kumar Panda
Jun 16, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nevin SağsözOnder Bozdoğan
May 17, 2005·Gynecologic Oncology·Synne KnoppRuth Holm
Apr 19, 2002·Biochimica Et Biophysica Acta·Sagrario OrtegaMariano Barbacid
Jan 12, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Leonie Little, Colin John Reid Stewart
Oct 3, 2002·Nature Medicine·Mirella LazarovPaul A Khavari
Apr 2, 2005·Cancer Cell International·S PadmaGayatri Ramakrishna
Feb 9, 2005·The Journal of Cell Biology·Jennifer Y ZhangPaul A Khavari
Sep 7, 2002·International Journal of Cancer. Journal International Du Cancer·Anju ZhangKeng-Ling Wallin
Jan 9, 2004·Cell Proliferation·M A ParkerR D Beauchamp
Mar 6, 2009·Veterinary Ophthalmology·Heather L ChandlerCarmen M H Colitz
Mar 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Robert Roskoski
May 19, 2007·Neurological Research·Jafri Malin AbdullahFauziah Othman
Jan 7, 2004·Cancer Cell·Ewa SicinskaPiotr Sicinski
Jan 18, 2006·Cancer Cell·Qunyan YuPiotr Sicinski
Mar 30, 2017·The Journal of Pathology·Maria Alba DosilXavier Dolcet
Nov 30, 2016·Obstetrics & Gynecology Science·Hyunsoo ParkHojung Lee
Jul 26, 2008·The Journal of International Medical Research·L D WangP L Li
Jun 29, 2004·International Journal of Cancer. Journal International Du Cancer·Heidi LyngPaula M De Angelis
Apr 20, 2005·Oncogene·Amit DeshpandePhilip W Hinds
Nov 1, 2005·Yonsei Medical Journal·Young Tae Kim, Min Zhao
Sep 20, 2006·Oncogene·P RojasM L Rodriguez-Puebla
Jun 27, 2012·Virchows Archiv : an International Journal of Pathology·M ChoschzickR Simon
Jun 18, 2003·Journal of Cellular Physiology·Karin Milde-Langosch, Sabine Riethdorf
Aug 19, 2007·Cancer Research·Mark W LandisPhilip W Hinds
Feb 21, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yudi XiongYunfeng Zhou

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