Alteration of cytokeratin 7 and cytokeratin 20 expression profile is uniquely associated with tumorigenesis of primary adenocarcinoma of the small intestine

The American Journal of Surgical Pathology
Zong-Ming E Chen, Hanlin L Wang


Twenty-four cases of primary nonampullary small intestinal adenocarcinoma were immunohistochemically examined for the expression of cytokeratin (CK) 7 and CK20 and compared with 23 colorectal adenocarcinomas secondarily involving the small intestine by direct extension or metastasis. While normal small intestinal mucosa was diffusely positive for CK20 and completely negative for CK7 expression, all small intestinal adenocarcinomas (24 of 24) showed a variable degree of CK7 expression. Specifically, the CK7 staining pattern was diffuse in 13 cases (54%) and focal in the remaining cases. Sixteen small intestinal adenocarcinomas (67%) coexpressed CK7 and CK20, and 8 (33%) completely lost CK20 immunoreactivity when compared with adjacent non-neoplastic small intestinal mucosa. In the latter cases, the loss of CK20 immunoreactivity with a reciprocal emergence of CK7 expression was evident. This was in contrast to secondary colorectal adenocarcinomas where 22 cases (96%) expressed CK20, among which only 1 case showed focal CK7 expression. The remaining 1 case was negative for both CK7 and CK20. Interestingly, adenomatous epithelium associated with small intestinal adenocarcinomas identified in 18 cases also exhibited CK7 positivity w...Continue Reading


Jan 1, 1991·British Journal of Cancer·R K RossB E Henderson
Apr 1, 1995·Japanese Journal of Cancer Research : Gann·K HibiH Takagi
Apr 1, 1994·Surgical Oncology·J H Donohue
Jan 1, 1996·Digestive Diseases and Sciences·T SutterP R Holt
Jul 1, 1996·Digestive Diseases·B G O'RiordanL Herrera
Oct 18, 1996·Cell·K W Kinzler, B Vogelstein
Aug 1, 1996·International Journal of Epidemiology·J S ChowA I Neugut
Dec 1, 1996·Digestive Diseases and Sciences·G Saracco, M Rizzetto
Feb 7, 1997·International Journal of Cancer. Journal International Du Cancer·M AraiT Ishikawa
Mar 26, 1998·British Journal of Cancer·A AchilleA Scarpa
Nov 20, 1998·The American Journal of Gastroenterology·P BenattiM Ponz de Leon
Jun 2, 2000·Gastroenterology·N ArberZ Halpern
Sep 28, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·P ChuL M Weiss
Dec 16, 2000·Digestive Diseases and Sciences·T MuneyukiR Yatani
Jul 14, 2001·ANZ Journal of Surgery·R R HutchinsS J Snooks
Oct 6, 2001·Journal of Clinical Gastroenterology·S S GillA A Mihas
Apr 9, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T Tot
May 16, 2002·Histopathology·P G Chu, L M Weiss
Feb 20, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dominique WendumJean-François Fléjou
Apr 19, 2003·QJM : Monthly Journal of the Association of Physicians·P D HowdleR S Houlston
May 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Min Jong LeeMihi Yang

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