PMID: 7542150Feb 1, 1995Paper

Alteration of cytokeratin expression in oral lichen planus

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
S BoisnicH Szpirglas

Abstract

The purpose of this investigation is to examine the possible biochemical and topographic cytokeratin alterations in lichen planus of oral mucosa. Biopsy samples of clinically normal buccal mucosa (n = 5), normal gingiva (n = 5), lichen planus from buccal mucosa (n = 5), and lichen planus from gingiva (n = 5) were obtained from patients of both sexes. Cytokeratin expression was determined by means of immunohistochemical labeling with use of a battery of monoclonal antibodies against cytokeratins and filaggrin and two-dimensional gel electrophoresis. In buccal mucosa, which is not keratinized cytokeratins 4 and 13 are expressed in the majority. In buccal mucosa lichen planus, the appearance of cytokeratins 1, 2, 10, and 11 coincides with a decrease in cytokeratins 4 and 13 and a moderate increase in cytokeratins 6, 16, 17, and 19. In normal gingiva, which is normally keratinized, the main cytokeratins are 1, 2, 10, and 11. In gingival lichen planus, a slight decrease in these cytokeratins and in cytokeratin 13 expression was noted. Finally, alterations in cytokeratins 5 and 14, explained by marked alterations of basal cells, were observed. The battery of antibodies used in this study, in correlation with two-dimensional gel elect...Continue Reading

Citations

Mar 6, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C ScullyD Wray
Apr 16, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Andreas KaratsaidisKarl Schenck
Oct 5, 2007·International Journal of Surgical Pathology·Ericka Janine Dantas da SilveiraLélia Maria Guedes Queiroz
Jun 16, 2010·Journal of Clinical Periodontology·Po-Chen HsiehKuo Yuan
Apr 28, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·S J Brown
Mar 15, 2018·BMC Oral Health·Sineepat TalungchitSiribang-On Piboonniyom Khovidhunkit
May 2, 2019·Journal of Cellular Physiology·Masoumeh MehrpouyaMorteza Oladnabi
Sep 2, 2020·European Journal of Oral Sciences·Olav SchreursKarl Schenck
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Jan 30, 2020·European Journal of Oral Sciences·Olav SchreursKarl Schenck
Mar 21, 1998·Journal of Cutaneous Pathology·H Biermann, E W Rauterberg
Dec 16, 2003·Skinmed·Claudio de Moura Castro JacquesMarcia Ramos-e-Silva
Feb 9, 2002·Oral Diseases·L M da Silva Fonseca, M A do Carmo
Sep 25, 2009·Journal of Oral Science·Claudio M C JacquesMarcia Ramos-e-Silva
Dec 22, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·K R LarsenA M L Pedersen
Oct 10, 2006·Journal of Cutaneous Pathology·Silvia Vanessa LourençoMarcello Menta Simonsen Nico
May 5, 1999·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P ChaiyaritR L Gregory
Aug 22, 2021·Oral Diseases·Edward OdellPhilip Sloan

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